Epidemiology articles within Nature Reviews Genetics

Featured

• Review Article | 05 June 2018

  Using genetic data to strengthen causal inference in observational research

  Various types of observational studies can provide statistical associations between factors, such as between an environmental exposure and a disease state. This Review discusses the various genetics-focused statistical methodologies that can move beyond mere associations to identify (or refute) various mechanisms of causality, with implications for responsibly managing risk factors in health care and the behavioural and social sciences.

  • Jean-Baptiste Pingault
  • , Paul F. O’Reilly
  •  & Frank Dudbridge

• Correspondence | 14 February 2018

  Heritable contributions versus genetic architecture

  • Nicholas J. Timpson
  • , Celia M. T. Greenwood
  •  & J. Brent Richards

• Correspondence | 14 February 2018

  Using partitioned heritability methods to explore genetic architecture

  • Luke M. Evans
  •  & Matthew C. Keller

• Review Article | 11 December 2017

  Genetic architecture: the shape of the genetic contribution to human traits and disease

  Genetic architecture describes the characteristics of genetic variation that are responsible for phenotypic variability. This Review discusses the types of genetic architecture that have been observed, how they can be measured and how genetic architecture informs the scientific and clinical goals of human genetics.

  • Nicholas J. Timpson
  • , Celia M. T. Greenwood
  •  & J. Brent Richards

• Research Highlight | 04 December 2017

  Genomics in the time of cholera

  • Carolina Perdigoto

• Research Highlight | 06 March 2012

  Many roads lead to commitment

  • Mary Muers

• Correspondence | 18 November 2011

  Response to 'Gene-by-environment experiments: a new approach to finding the missing heritability' by van IJzendoorn et al.

  • Duncan Thomas