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Breast cancer is caused by the development of malignant cells in the breast. The malignant cells originate in the lining of the milk glands or ducts of the breast (ductal epithelium). Breast cancer is the most common cancer in women, but it can also appear in men.
The physicochemical properties of cationic helical polypeptides can be optimized to induce endoplasmic reticulum stress in antigen-presenting cells so as to elicit antitumour innate immune responses.
Breast cancer metastasis to the brain is rising in prevalence and is an increasingly lethal threat to the patients. Here, the authors show miR-199b-5p, secreted by some breast cancer cells and detected at a higher level in patients with brain metastases, impairs the metabolic coupling between neurons and astrocytes to facilitate development of brain metastasis.
The physicochemical properties of cationic helical polypeptides can be optimized to induce endoplasmic reticulum stress in antigen-presenting cells so as to elicit antitumour innate immune responses.
This study by Chen et al. reveals that a high-fat diet leads to a predominance of Desulfovibrio species in the gut, correlating with a poor prognosis of breast cancer.
We have curated a comprehensive single-cell reference map of the human breast. Our data explore how age, parity and germline mutations might influence cellular dynamics, revealing unexpected signs of immune exhaustion in healthy tissues from carriers of BRCA1 or BRCA2 germline mutations.