Research Highlight |
Featured
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Research Highlight |
Human protein mutagens found via bacteria
A new study published in Cell uses bacterial genetic screens to identify mutagenic proteins. Overexpression of homologues of these proteins in human cells has similar mutagenic effects and potential prognostic value in cancer.
- Darren J. Burgess
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Review Article |
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
Biomarkers of ageing based on DNA methylation data enable accurate age estimates for any tissue across the entire life course. Horvath and Raj review the development of these ‘epigenetic clocks’ and how they link to biological ageing.
- Steve Horvath
- & Kenneth Raj
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Review Article |
Cancer transcriptome profiling at the juncture of clinical translation
Although cancer genome sequencing is becoming routine in cancer research, cancer transcriptome profiling through methods such as RNA sequencing (RNA-seq) provides information not only on mutations but also on their functional cellular consequences. This Review discusses how technical and analytical advances in cancer transcriptomics have provided various clinically valuable insights into gene expression signatures, driver gene prioritization, cancer microenvironments, immuno-oncology and prognostic biomarkers.
- Marcin Cieślik
- & Arul M. Chinnaiyan
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Review Article |
Translating RNA sequencing into clinical diagnostics: opportunities and challenges
RNA sequencing (RNA-seq) is a powerful approach for comprehensive analyses of transcriptomes. This Review describes the widespread potential applications of RNA-seq in clinical medicine, such as detecting disease-associated mutations and gene expression disruptions, as well as characteristic non-coding RNAs, circulating extracellular RNAs or pathogen RNAs. The authors also highlight the challenges in adopting RNA-seq routinely into clinical practice.
- Sara A. Byron
- , Kendall R. Van Keuren-Jensen
- & David W. Craig
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Detecting pregnancy complications from blood