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To those who seek transcriptomic information at high resolution, scale and throughput, single-cell RNA sequencing brings the data. Scientists share tips and future plans as they reflect on the method’s rise to stardom.
Collaborations between researchers and companies can progress swimmingly and teams quickly validate findings and mature methods. All too often, things can’t advance and the ‘Valley of Death’ looms. New ways to collaborate, underpinned by computational muscle, can help.
As money pours into aging research, the field can combine its many methods to home in on what underpins aging. Approaches differ, but researchers share the desire to not overpromise quick-fix anti-aging methods.
Researchers like the gene-editing method called prime editing for its precision and versatility. As they ask the method to do more, many factors shape what happens next.
Wrangling big data is now part of being a biomedical scientist, and mandates on data sharing have entered the scene. Mandates can alter behavior, but data sharing also needs incentives and shifts in science culture.
To gain insight into cell function, researchers are tracking the cytoskeleton and its parts, such as actin. They combine methods, find new trackers and validate them.
A rapidly evolving toolbox is helping researchers to get a handle on the biological and functional diversity of these ubiquitous — but still somewhat enigmatic — cell-secreted nanoparticles
As new technology enables researchers to find and characterize less-common post-translational modifications that drive gene expression and cellular metabolism, the movement to catalog the entire human proteome gains momentum