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Heterogeneity in growth phenotypes and drug susceptibility in bacterial and mammalian cells are assayed at the single-cell level using multiplexed resonant mass sensors.
DNA methyl groups are selectively removed at target loci using inactive Cas9 fused to a SunTag-based peptide repeat that recruits the enzymatic activity.
Sources of error and bias in PCR amplification of microbial samples for 16S rRNA gene sequencing are systematically evaluated, and best-practice recommendations for reliable amplification are made.
Softening in tomatoes is uncoupled from ripening by silencing a pectate lyase, thereby identifying a route to engineering (or breeding) tomatoes with better shelf life and flavor.
Protease-free expansion of organ-size tissue enables multiplexed super-resolution imaging of protein organization from the tissue-wide scale down through the nanoscale.
Canola oil containing healthful long chain omega-3 polyunsaturated fatty acids is produced from plants engineered with an algal polyketide synthase-like enzyme system.
Analyzing and integrating a broad range of behavioral phenotypes enables prediction of underlying genetic mutations in mouse models of Huntington's disease.
Simultaneous imaging of neural activity in large regions of the mouse brain at subcellular resolution is made possible with a wide field-of-view two-photon microscope.