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Optimized algorithms from the field of electrical-signal processing improve the identification of genomic signals from diverse high-throughput sequencing experiments, such as ChIP-seq, DNase-seq and FAIRE-seq.
An approach involving combinatorial peptide–MHC tetramer staining and mass cytometry allows simultaneous screening of over 100 T-cell specificities in a single human blood sample.
Gene therapy encoding a single influenza broadly neutralizing antibody durably protects even immunocompromised mice from illness caused by diverse influenza strains.
Zwitterionic hydrogels may be a useful biocompatible material, as they resist collagen capsule formation yet promote angiogenesis after implantation in mice.
Covalent links formed between methylation enzymes and a 5-azacytidine base incorporated into cellular RNA allow target enrichment and single base-pair resolution modification mapping.
Two studies show direct conversion of mouse embryonic fibroblasts to oligodendrocyte progenitor cells capable of generating myelinating oligodendrocytes.
Two studies show direct conversion of mouse embryonic fibroblasts to oligodendrocyte progenitor cells capable of generating myelinating oligodendrocytes.
A library of in vitro translated human proteins tethered to their encoding mRNAs is used for unbiased discovery of interactions with immobilized proteins, autoantibodies or small molecules.
A computational pipeline identifies genetic variants that affect transcriptional responses to stimuli, and uses this information to refine molecular circuits.