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The immune system can recognize and destroy malignant cells, providing an important defense against the development of cancer. Therefore, successful cancers must learn to evade the immune system both during development and in the process of metastasis. The approaches taken range from promoting the infiltration and activation of protumorigenic immune cells to downregulating immune checkpoint proteins. Understanding the mechanisms by which cancers evade the immune system is imperative to understanding host-tumor interactions, identifying new treatments, and improving current immunotherapies.
This Collection welcomes original research examining immune evasion in cancer, including studies examining mechanisms of immune evasion and immunotherapies targeting immune evasion.