Leveraging mucosal immunity
- Submission status
- Open
- Submission deadline
The mucosal system covers the respiratory, digestive and genitourinary tracts as well as the conjunctiva of the eye, the inner ear and the ducts of all exocrine glands. Featured with an extensive surface area constantly exposed to the outside world, the mucosal system therefore greatly relies on the protection of a highly specialized innate and adaptive mucosal immune system. The mucosal immune system, mainly the mucosa-associated lymphoid tissues, has to be exclusively dedicated in enduring the constant threats of exogenous particles, food debris, allergens, pathogenic or commensal microorganisms, even viruses. Under an excessive external stimuli, the mucosal immune system is more adept at balancing various effectors to maintain immune equilibrium from evoking infection and averting inflammation, as well as evading bystander damage and immune depletion, which differs from the systemic immune system working in an internal clean environment and responding strongly to all attackers.
Based on the multifunctional role of the mucosal immune system, this collection aims at all aspects of mucosal immunity from function to treatment. Topics of interest include dysregulated inflammation, immune tolerance, respiratory or digestive tract allergy, asthma, infection, wound, cancer, drug, vaccines, and probiotics. Beyond pertinent diseases and treatments , we also welcome the systematic perspectives such as intestinal neuro-immune axis, gut–lung axis, epithelial-stromal crosstalk, and comprehensive interactions within immune cells, microbes and viruses.
This Collection welcomes original research on all aspects of mucosal immunology.
Editors
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Cheng-Yuan Kao, PhD
Inflammation Therapeutic Area, Amgen, San Francisco, United States
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Mehmet Kesimer, PhD
Department of Pathology and Laboratory Medicine, Marsico Lung Institute, University of North Carolina at Chapel Hill
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Shajan Peter, MD, FACG, FASGE, AGAF
Division of Gastroenterology and Hepatology, University of Alabama, United States
