Our study investigated microbial dynamics involved in the relative enrichment of oral bacteria in faeces. Results in mice and from human patients indicated that high percentages of oral bacteria reflect a depleted gut microbiota, with oral bacteria simply passing through rather than expanding in the gut, which has implications for gastrointestinal disease treatment.
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References
The Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 486, 207–214 (2012). The Human Microbiome Project catalogued the distinct populations residing in different body sites.
Zarrinpar, A. et al. Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism. Nat. Commun. 9, 2872 (2018). This paper used quantitative microbiome profiling to determine the damage caused by antibiotics.
Kitamoto, S., Nagao-Kitamoto, H., Hein, R., Schmidt, T. & Kamada, N. The bacterial connection between the oral cavity and the gut diseases. J. Dent. Res. 99, 1021–1029 (2020). This review article discusses links between oral bacteria and gut diseases.
Liao, C. et al. Compilation of longitudinal microbiota data and hospitalome from hematopoietic cell transplantation patients. Sci. Data 8, 71 (2021). A large compilation of patients’ microbiome data with clinical metadata.
Taur, Y. et al. Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant. Sci. Transl. Med. 10, eaap9489 (2018). A pilot trial demonstrated the feasibility of autologous faecal microbiota transplantation to reconstitute antibiotic-depleted intestinal microbiota during allogeneic haematopoietic cell transplantation.
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This is a summary of: Liao, C. et al. Oral bacteria relative abundance in faeces increases due to gut microbiota depletion and is linked with patient outcomes. Nat. Microbiol. https://doi.org/10.1038/s41564-024-01680-3 (2024).
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The meaning of oral bacteria in faeces. Nat Microbiol (2024). https://doi.org/10.1038/s41564-024-01692-z
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DOI: https://doi.org/10.1038/s41564-024-01692-z