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We present a method to alleviate re-identification risks behind sharing haplotype reference panels for imputation. In an anonymized reference panel, one might try to infer the genomes’ phenotypes to re-identify their owner. Our method protects against such attack by shuffling the reference panels genomes while maintaining imputation accuracy.
Multicellular modeling is increasingly being used to understand biological systems. SimuCell3D is a tool that allows mechanically realistic simulations, using the deformable cell model, to be developed and run.
The authors develop a web resource to present pan-cancer mutations in 32 major types of cancer. This new online somatic mutations atlas, OncoDB is publicly available at https://oncodb.org.
Using a dependency-aware deep generative framework, spaVAE efficiently models spatially resolved transcriptomics data and advances diverse analysis tasks. Following similar strategies, spaPeakVAE and spaMultiVAE enable spatial ATAC-seq data and spatial multi-omics data modeling and analysis, respectively.
TAD hierarchy demonstrates cell-to-cell variability, leading to the development of numerous callers. Here, authors present a comprehensive benchmark of TAD hierarchy callers and introduce the ‘air conditioner’ model to illustrate TAD hierarchy’s role in transcription.
We present a method to alleviate re-identification risks behind sharing haplotype reference panels for imputation. In an anonymized reference panel, one might try to infer the genomes’ phenotypes to re-identify their owner. Our method protects against such attack by shuffling the reference panels genomes while maintaining imputation accuracy.
In this Tools of the Trade article, Vipul Singhal and Nigel Chou describe BANKSY, a machine learning tool that harnesses gene expression gradients from the neighbourhood of a cell for cell typing and domain segmentation.
Multicellular modeling is increasingly being used to understand biological systems. SimuCell3D is a tool that allows mechanically realistic simulations, using the deformable cell model, to be developed and run.