Research articles

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  • Two species of auxotrophic marine bacteria are shown to share precursors to synthesize the essential cofactor vitamin B12, and such ligand cross-feeding may be a common phenomenon in the ocean and other ecosystems.

    • Gerrit Wienhausen
    • Cristina Moraru
    • Meinhard Simon
    Article
  • Detailed analyses of the serotonin receptor 5-HT1A and the psychedelic 5-methoxy-N,N-dimethyltryptamine reveal the differences in receptor structural pharmacology that mediate signalling specificity, efficacy and potency, findings that may facilitate the development of new neuropsychiatric therapeutics.

    • Audrey L. Warren
    • David Lankri
    • Daniel Wacker
    Article
  • Boson sampling using ultracold atoms in a two-dimensional, tunnel-coupled optical lattice is enabled by high-fidelity programmable control with optical tweezers of a large number of atoms trapped in an optical lattice.

    • Aaron W. Young
    • Shawn Geller
    • Adam M. Kaufman
    Article
  • The geological histories of Archaean regions indicate that stabilization of the Earth’s continents and the formation of cratons was driven by continental emergence and subaerial weathering.

    • Jesse R. Reimink
    • Andrew J. Smye
    ArticleOpen Access
  • Biochemical screening and optimization identify small molecules that inhibit the formation of lipoprotein(a), and these inhibitors reduce the levels of Lp(a) in several animal models, suggesting that they could provide a therapeutic option in humans.

    • Nuria Diaz
    • Carlos Perez
    • Laura F. Michael
    ArticleOpen Access
  • Enhanced light–molecule interactions in high-finesse fibre-based Fabry–Pérot microcavities are used to detect and profile individual unlabelled solution-phase biomolecules, leading to potential applications in the life and chemical sciences.

    • Lisa-Maria Needham
    • Carlos Saavedra
    • Randall H. Goldsmith
    Article
  • A new method based on the Josephson effect is described, allowing to measure the superfluid fraction of a supersolid, which captures the effect of spatially periodic modulation leading to reduction in the stiffness of superfluids.

    • G. Biagioni
    • N. Antolini
    • G. Modugno
    ArticleOpen Access
  • Electro-optical photonic integrated circuits based on lithium tantalate perform as well as current state-of-the-art ones using lithium niobate but the material has the advantage of existing commercial uses in consumer electronics, easing the problem of scalability.

    • Chengli Wang
    • Zihan Li
    • Tobias J. Kippenberg
    ArticleOpen Access
  • Using a Bayesian learning approach, a study tracks the spatial representations by individual hippocampal cells over time in freely moving rats, and provides insights into how ensemble patterns form and reconfigure during sleep.

    • Kourosh Maboudi
    • Bapun Giri
    • Kamran Diba
    Article
  • Reducing greenhouse gas emissions, managing ecosystem health, and preventing biological invasions and biodiversity loss could help to reduce the burden of plant, animal and human diseases, especially when coupled with improvements to social and economic determinants of health.

    • Michael B. Mahon
    • Alexandra Sack
    • Jason R. Rohr
    Article
  • Using an optical resonator containing two individually addressable atoms in a single cavity, fusion of deterministically generated photonic graph states to create ring and tree graph states with up to eight qubits is demonstrated.

    • Philip Thomas
    • Leonardo Ruscio
    • Gerhard Rempe
    ArticleOpen Access
  • QS-21—an FDA-approved vaccine adjuvant—and several structural analogues of QS-21 can be synthesized in engineered yeast strains, and this process is much less laborious compared with the conventional mode of extraction from the Chilean soapbark tree.

    • Yuzhong Liu
    • Xixi Zhao
    • Jay D. Keasling
    ArticleOpen Access