Research articles

Two species of auxotrophic marine bacteria are shown to share precursors to synthesize the essential cofactor vitamin B₁₂, and such ligand cross-feeding may be a common phenomenon in the ocean and other ecosystems.

Detailed analyses of the serotonin receptor 5-HT_1A and the psychedelic 5-methoxy-N,N-dimethyltryptamine reveal the differences in receptor structural pharmacology that mediate signalling specificity, efficacy and potency, findings that may facilitate the development of new neuropsychiatric therapeutics.

Boson sampling using ultracold atoms in a two-dimensional, tunnel-coupled optical lattice is enabled by high-fidelity programmable control with optical tweezers of a large number of atoms trapped in an optical lattice.

A triangular-lattice Hubbard system realized with ultracold atoms is used to directly image spin polarons, revealing ferromagnetic correlations around a charge dopant, a manifestation of the Nagaoka effect.

We report on a near-zero-power flexible heat pump that uses both electrocaloric and electrostrictive properties of a tailored polymer to create a chip-scale refrigerator device.

Using a multimodal approach across acute leukaemias, a targetable PI3Kγ dependency in leukaemias is explored.

Improving the long-range order of the quantum dots in perovskite LEDs can markedly enhance their operational stability.

The geological histories of Archaean regions indicate that stabilization of the Earth’s continents and the formation of cratons was driven by continental emergence and subaerial weathering.

Biochemical screening and optimization identify small molecules that inhibit the formation of lipoprotein(a), and these inhibitors reduce the levels of Lp(a) in several animal models, suggesting that they could provide a therapeutic option in humans.

Enhanced light–molecule interactions in high-finesse fibre-based Fabry–Pérot microcavities are used to detect and profile individual unlabelled solution-phase biomolecules, leading to potential applications in the life and chemical sciences.

By demonstrating a computational approach to restore the clinical efficacy of a COVID-19 antibody, the potential to rapidly update clinical antibodies is explored.

A molecular design strategy for reducing the vibration-induced non-radiative losses in emissive organic semiconductors is realized by decoupling excitons from high-frequency vibrations.

A new method based on the Josephson effect is described, allowing to measure the superfluid fraction of a supersolid, which captures the effect of spatially periodic modulation leading to reduction in the stiffness of superfluids.

Electro-optical photonic integrated circuits based on lithium tantalate perform as well as current state-of-the-art ones using lithium niobate but the material has the advantage of existing commercial uses in consumer electronics, easing the problem of scalability.

Using a Bayesian learning approach, a study tracks the spatial representations by individual hippocampal cells over time in freely moving rats, and provides insights into how ensemble patterns form and reconfigure during sleep.

Reducing greenhouse gas emissions, managing ecosystem health, and preventing biological invasions and biodiversity loss could help to reduce the burden of plant, animal and human diseases, especially when coupled with improvements to social and economic determinants of health.

Using an optical resonator containing two individually addressable atoms in a single cavity, fusion of deterministically generated photonic graph states to create ring and tree graph states with up to eight qubits is demonstrated.

QS-21—an FDA-approved vaccine adjuvant—and several structural analogues of QS-21 can be synthesized in engineered yeast strains, and this process is much less laborious compared with the conventional mode of extraction from the Chilean soapbark tree.

A type of qubit that has inherent resistance to bit-flip errors has been manipulated with a bit-flip time of more than 10 s without losing that error protection.

Water loss to space late in Venus history is shown to be more active than previously thought, with unmeasured HCO⁺ dissociative recombination dominating present-day H loss.