The SINE transposable element upstream of the ISL1 gene serves to enhance gene expression.
A reporter assay shows that the SINE transposon, when activated, is expressed in the same regions (a) as the ISL1 gene (b). Gene expression is shown in blue. On the bottom are close-up images of the expression similarities along the geminal eminance. The arrow points out the staining in the dorsal apical ectodermal ridge.
This image is linked to the following World Library of Science pages:
