The presence of peaks in crossover activity, which are embedded in 'cold' DNA, are reminiscent of recombination patterns in maize and might be typical of higher eukaryotes with complex genomes.
Genes in the region are shown as boxes above the plot. The peaks in recombination activity represent the six crossover hot spots characterized by sperm analyses (see main text). The approximate recombination rate for inter-hot-spot DNA segments is given in millicentiMorgans (mcM, cMx10-3). The most active crossover hot spot, DNA3 is indicated with a dashed box.
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Deletions and duplications of single-base pairs typically arise during homologous recombination and cause diseases. But what happens when a mutation occurs over multiple genes?
