The figure shows the protein products of the genes for which there is evidence of direct transcriptional activation by hypoxia-inducible factor (HIF). Differentiated embryo chrondrocyte (DEC)1 and DEC2 are transcription factors of the basic helix–loop–helix family. ETS is a DNA-binding domain that defines a family of transcription factors. p35srj is a 35-kDa protein that contains a serine/glycine-rich junction. Nip3 is a member of the Bcl2 family of cell-death factors. CXCR is a receptor for the CXC family of chemokines. c-Met is the tyrosine-kinase product of the met proto-oncogene.
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How can low oxygen levels lead to developmental abnormality and disease? It seems that proteins called hypoxia-inducible factors (HIFs) can affect gene expression in low-oxygen conditions.
