Spatial Proteomics: Advances in Technologies and Applications

Date: This event took place on September 8, 2021

An overview of spatially-resolved proteomics, with a special focus on methodologies for high-multiplex imaging using fluorescent- or metal-based antibodies will be provided in this webcast. As two experts in the field, Cecilia Lindskog (Uppsala University & Human Protein Atlas) will discuss fluorescent antibody-based approaches for spatial analysis of tissue and cell type-specific protein expression patterns and Jared K. Burks (University of Texas MD Anderson Cancer Center) will highlight the use of Imaging Mass Cytometry to investigate the tumor microenvironment at a single-cell level.

The 60-minute webinar will be structured as two 15-minute talks by our speakers, each covering both an introduction to the method and examples of applications that leverage these technologies to answer interesting research questions. These talks will be followed by a 30-minute Q&A session with the audience, in which we will aim to compare the two methods among others, and discuss which research questions are best suited to each approach. Moderators will facilitate the discussion and pass on questions from the audience.

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Speakers

  • Cecilia Lindskog, Uppsala University

    Cecilia Lindskog, Uppsala University

    Dr. Lindskog is a group leader at Uppsala University, Uppsala, Sweden. Her research focuses on integration of transcriptomics and antibody-based proteomics, linking cell type specificity with function and mechanisms of disease. She has a PhD in pathology from the Faculty of Medicine, Uppsala University, and joined the Human Protein Atlas already in the early stage of the project, more than 15 years ago. Dr. Lindskog is heading the tissue-based profiling of the Human Protein Atlas, with main emphasis on immunohistochemistry, antibody validation and cell type-specific localization in human normal and cancer tissues.

  • Jared K. Burks, The University of Texas MD Anderson Cancer Center

    Jared K. Burks, The University of Texas MD Anderson Cancer Center

    Dr. Burks is an associate professor at the University of Texas MD Anderson Cancer Center, and the co-director of its Flow Cytometry & Cell Imaging Core Facility. In this role, he implements different microscopy techniques , as well as mass cytometry, and CyTOF with an emphasis on live cell spinning disk confocal imaging. He supports researchers as they leverage these technologies to study the spatial distribution and functional interactions of cells in the tumor microenvironment. He pursued a PhD at Texas A&M University and post-doctoral research at Baylor College of Medicine, where he studied viral protein trafficking in infected cells.

  • Aline Lueckgen, Nature Communications

    Moderator: Aline Lueckgen, Nature Communications

    Aline joined Nature Communications in June 2020, where she handles manuscripts in the areas of bioengineering, biomaterials, and single-cell approaches. After obtaining her Master’s degree in bioengineering at the EPFL in Switzerland, she completed her PhD at the Technical University in Berlin. In her doctoral work, she investigated the degradation behavior of alginate-based hydrogels.

  • Ilse Valtierra, Nature Communications

    Moderator: Ilse Valtierra, Nature Communications

    Ilse joined Nature Communications in June 2020, where she handles manuscripts in cancer genomics. She obtained her PhD from the Ludwig Maximilian University of Munich, where she studied clonal heterogeneity and evolution in acute myeloid leukaemia using bulk and single-cell genomics. Before that, she obtained her Master’s from Heidelberg University and her Bachelor’s from the National Autonomous University of Mexico.

  • Stacey-Lynn Paiva, Nature Reviews Methods Primers

    Moderator: Stacey-Lynn Paiva, Nature Reviews Methods Primers

    Following a PhD in chemistry at the University of Toronto, Stacey conducted postdoctoral work in chemical biology at Yale University. Stacey started her editorial career at Nature Reviews Drug Discovery in September 2019 and assumed her current role on the launch team for Nature Reviews Methods Primers in March 2020. Stacey primarily handles papers in chemistry and chemical biology.