Custom Single-cell and computational analysis in targeted immunotherapies

Date: This event took place on June 1, 2021

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Immunotherapies to treat cancer have achieved remarkable successes, but an inherent weakness of current treatment approaches is that the targeted immune subsets are not exclusive to tumors.

This webcast will describe the use of complementary single-cell analysis approaches to identify tumor-unique immune features that are distinct from general inflammatory processes.

The speaker will explain the composition of the immune infiltrate in the human tumor microenvironment as a critical determinant of disease progression. Comparison of the immune landscape in human tumors and site-matched non-malignant, inflamed tissue samples shows phenotypic congruence of the immune infiltrate in inflamed tissues with the tumor.

However, computational analyses identified putative, tumor-unique signaling networks between antigen-presenting cells (APCs) and regulatory T cells (Tregs). Subsequent experimental validation confirmed an intratumoral IL-1 network between APCs and Tregs. These intratumoral Tregs were uniquely identified by ICOS and IL-1R1 cell surface expression, thus allowing for tumor-specific depletion.

Explore:

  • Which immune signatures distinguish tumor-unique inflammation from general tissue inflammation?
  • Can this approach identify potentially novel immunotherapeutic targets?
  • How to best leverage advanced single-call analysis pipelines to gain insight into human immune function?

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Speakers

  • Dr.Florian Mair, Fred Hutchinson Cancer Research Center

    Dr.Florian Mair, Fred Hutchinson Cancer Research Center

    Florian Mair obtained his Ph.D. from the University of Zurich and is an immunologist at the FHCRC in Seattle. His focus is advanced single-cell techniques to understand the function of antigen-presenting cells and T cells in human tissues. He is an ISAC scholar and AAI Computational Intersect fellow.

  • Dr. Jayshan Carpen, Springer Nature

    Moderator: Dr. Jayshan Carpen, Springer Nature

    Jayshan is a Senior Publishing Manager for Springer Nature and oversees the custom multimedia unit. Previously he ran science events at the Royal Institution of Great Britain. He received his PhD from the University of Surrey, UK in Neurogenetics. His doctoral thesis focused on identifying polymorphisms associated with diurnal preference and circadian sleep disorders.