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Epigenetics

A new methyl mark on messengers

The presence of an N1 methyl group on adenine bases in DNA and RNA was thought to be a form of damage. Results now show that it also occurs at specific sites in messenger RNAs, where it affects protein expression. See Article p.441

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Figure 1: Dynamic methylation of adenine.

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References

  1. Meyer, K. D. & Jaffrey, S. R. Nature Rev. Mol. Cell Biol. 15, 313–326 (2014).

    Article  CAS  Google Scholar 

  2. Fu, Y., Dominissini, D., Rechavi, G. & He, C. Nature Rev. Genet. 15, 293–306 (2014).

    Article  CAS  Google Scholar 

  3. Edelheit, S., Schwartz, S., Mumbach, M. R., Wurtzel, O. & Sorek, R. PLoS Genet. 9, e1003602 (2013).

    Article  CAS  Google Scholar 

  4. Dominissini, D. et al. Nature 530, 441–446 (2016).

    Article  CAS  ADS  Google Scholar 

  5. Mishima, E. et al. J. Am. Soc. Nephrol. 25, 2316–2326 (2014).

    Article  CAS  Google Scholar 

  6. Helm, M., Giegé, R. & Florentz, C. Biochemistry 38, 13338–13346 (1999).

    Article  CAS  Google Scholar 

  7. He, C. et al. Mol. Cell 20, 117–129 (2005).

    Article  CAS  Google Scholar 

  8. Macon, J. B. & Wolfenden, R. Biochemistry 7, 3453–3458 (1968).

    Article  CAS  Google Scholar 

  9. Singer, B. & Grunberger, D. Molecular Biology of Mutagens and Carcinogens (Plenum, 1983).

    Book  Google Scholar 

  10. Aas, P. A. et al. Nature 421, 859–863 (2003).

    Article  CAS  ADS  Google Scholar 

  11. Li, X. et al. Nature Chem. Biol. http://dx.doi.org/10.1038/nchembio.2040 (2016).

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Correspondence to Anna M. Kietrys or Eric T. Kool.

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Kietrys, A., Kool, E. A new methyl mark on messengers. Nature 530, 423–424 (2016). https://doi.org/10.1038/530423a

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