Zebrafish (Danio rerio) is a small freshwater fish that is an extensively studied vertebrate model organism. It can be bred rapidly in large numbers, is amenable to genetics, and has a clear embryo, making it attractive to study vertebrate development, physiology and disease.

Latest Research and Reviews

News and Comment

  • News & Views |

    Optogenetic and thermogenetic tools have been limited to applications for single-state control of cellular processes. A single-component optogenetic tool was found to act as both a temperature sensor and a photoreceptor, enabling multi-state control of developmental signaling.

    • Maxwell Z. Wilson
  • News & Views |

    How lymphatic vessels arise from veins is still poorly understood. A study reports the discovery of a ribosome biogenesis regulator Ddx21 as a previously unappreciated specific factor that is important for the first steps of lymphatic but not blood vessel development. The finding may lead to better strategies to selectively target lymphangiogenesis.

    • Severin Mühleder
    •  & Rui Benedito
    Nature Cell Biology 23, 1109-1110
  • News & Views |

    A new CRISPR/Cas9 method that can generate F0 mutant zebrafish has the potential to cut costs, spare time, and reduce animal use for researchers interested in screening loss-of-function alleles in vivo.

    • Wouter Masselink
    Lab Animal 50, 95-96
  • News & Views |

    To achieve knockdown rather than knockout of particular genes, a new paper demonstrates a CRISPR/Cas13 method that can efficiently edit mRNA in zebrafish, medaka, killifish, and mouse embryos.

    • Rebecca Leech
    •  & Karuna Sampath
    Lab Animal 49, 317-319