White matter disease articles from across Nature Portfolio

In this Review, the authors provide an overview of evidence that activity-regulated myelination is required for brain adaptation and learning, and discuss how dysregulation of activity-dependent myelination contributes to neurological disease and could be a new therapeutic target.

The analysis of autopsy material from individuals with multiple sclerosis with single-cell transcriptomics and ¹⁴C carbon dating calls for a reevaluation of mature oligodendrocytes in myelin repair.