Voltage clamp articles within Nature Communications

Featured

• Article
  11 May 2023 | Open Access

  Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1

  TRPV1 is a noxious heat sensor. Here, authors showed that tailed amphibians express TRPV1 with a reduced heat-activation threshold by substitution of two amino acids in the N-terminal region to contribute to cool-habitat selection.

  • Shogo Hori
  • , Michihiro Tateyama
  •  & Osamu Saitoh

• Article
  25 November 2022 | Open Access

  Gating and ion selectivity of Channelrhodopsins are critical for photo-activated orientation of Chlamydomonas as shown by in vivo point mutation

  Channelrhodopsin photoreceptors are responsible for phototaxis in C. reinhardtii. Here, authors introduce point mutations in the channel which modify photocycle kinetics and ion selectivity, resulting in a deeper understanding of phototaxis in low light conditions.

  • Olga Baidukova
  • , Johannes Oppermann
  •  & Peter Hegemann

• Article
  10 May 2021 | Open Access

  Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease

  Synaptic loss may disturb the excitatory to inhibitory balance (E/I ratio) in circuits vulnerable in Alzheimer’s disease (AD). The authors find reduced synaptic levels of PSD-95 and gephyrin and show that individuals with AD exhibit a pro-excitatory shift of postsynaptic densities and the electrophysiological synaptic E/I ratio in the parietal cortex.

  • Julie C. Lauterborn
  • , Pietro Scaduto
  •  & Agenor Limon