Virus structures

Virus structures are the physical components of a virus particle, including its genome and structural proteins.

Latest Research and Reviews

  • Reviews |

    Recent crystallography and electron microscopy studies have refined our model of herpesvirus entry into cells. In this Review, Connolly, Jardetzky and Longnecker discuss recent insights into herpesvirus entry by analysing the structures of entry glycoproteins, including the diverse receptor-binding glycoproteins and conserved fusion proteins.

    • Sarah A. Connolly
    • , Theodore S. Jardetzky
    •  & Richard Longnecker
  • Reviews |

    The textbook view of the viral life cycle depicts uniform, discrete steps. However, growing evidence shows considerable phenotypic and morphological heterogeneity during viral infection. In this Review, Lakdawala and colleagues highlight host and viral heterogeneity and its causes and consequences.

    • Jennifer E. Jones
    • , Valerie Le Sage
    •  & Seema S. Lakdawala
  • Research
    | Open Access

    Here, the authors provide a 3.4 Å resolution structure of mature Zika virus (ZIKV) and identify two lipid moieties, coordinated by hydrophobic residues of the M and E transmembrane helices and between two helices of E protein, that play an essential role in the ZIKV assembly pathway.

    • Nadia M. DiNunno
    • , Daniel J. Goetschius
    • , Anoop Narayanan
    • , Sydney A. Majowicz
    • , Ibrahim Moustafa
    • , Carol M. Bator
    • , Susan L. Hafenstein
    •  & Joyce Jose
  • Research
    | Open Access

    Varicella-zoster virus (VZV) is the causative agent of chickenpox and herpes zoster (shingles). Cryo-EM structure of VZV capsid provides insights into the capsid assembly and reveals a pocket that could potentially be targeted by antiviral drugs.

    • Junqing Sun
    • , Congcong Liu
    • , Ruchao Peng
    • , Fu-Kun Zhang
    • , Zhou Tong
    • , Sheng Liu
    • , Yi Shi
    • , Zhennan Zhao
    • , Wen-Bo Zeng
    • , George Fu Gao
    • , Hong-Jie Shen
    • , Xiaoming Yang
    • , Minhua Luo
    • , Jianxun Qi
    •  & Peiyi Wang
  • Research
    | Open Access

    Human coronavirus-HKU1 contains two surface projections called spike and haemagglutinin-esterase (HE), with the latter acting as a receptor-destroying enzyme. Here, the authors use cryo-EM and mass spectrometry to characterise the small, heavily glycosylated HKU1 HE, revealing a vestigial lectin domain covered with a putative glycan shield; and they discuss these features in the context of host adaptation.

    • Daniel L. Hurdiss
    • , Ieva Drulyte
    • , Yifei Lang
    • , Tatiana M. Shamorkina
    • , Matti F. Pronker
    • , Frank J. M. van Kuppeveld
    • , Joost Snijder
    •  & Raoul J. de Groot
  • Research |

    Cryo-electron microscopy structures of three varicella-zoster virus (VZV) capsids show VZV-specific features of the capsid-associated tegument complex (CATC) and genome packaging. The authors conclude that the VZV capsid is less stable and the CATC binds more weakly than in the homologues in other herpesviruses, characteristics that are linked to the small genome size of VZV.

    • Wei Wang
    • , Qingbing Zheng
    • , Dequan Pan
    • , Hai Yu
    • , Wenkun Fu
    • , Jian Liu
    • , Maozhou He
    • , Rui Zhu
    • , Yuze Cai
    • , Yang Huang
    • , Zhenghui Zha
    • , Zhenqin Chen
    • , Xiangzhong Ye
    • , Jinle Han
    • , Yuqiong Que
    • , Ting Wu
    • , Jun Zhang
    • , Shaowei Li
    • , Hua Zhu
    • , Z. Hong Zhou
    • , Tong Cheng
    •  & Ningshao Xia

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