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Single-particle cryo-electron microscopy structures of HIV-1 envelope (Env) trimers bound to one or two CD4 receptors identify intermediate Env conformations that precede host–virus fusion and inform the design of therapeutics to prevent HIV-1 infection.
To read and transcribe the viral genome, the polymerase complex of human metapneumovirus (HMPV) needs to attach to the nucleocapsid. Here, the authors define the dynamic basis of how the polymerase cofactor P facilitates this attachment.
Baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is used as a bioinsecticide and a protein expression vector. Here, the authors report structures of cylindrical body of the AcMNPV nucleocapsid, as well as of both the nucleocapsid head and base.
Here the authors unveil the assembly of a cyanophage in its native form, providing insights into DNA gating and infection process of tailed phages. They proposed structure-based analysis for virus evolution and classification.
The severe fever with thrombocytopenia syndrome virus (SFTSV, officially named Dabie bandavirus) is a tick-borne human-infecting bunyavirus. Here, the authors report the cryo-EM structure of SFTSV virion, and discuss the mechanisms of viral assembly, membrane fusion and antibody neutralization.
This study reveals that a cross-neutralizing antibody targets a conserved site on betacoronavirus spike proteins and confers protection against SARS-CoV-2 infection.
This study provides ultrastructural evidence that the HIV-1 capsid can enter the nucleus of an infected T cell line through the nuclear pore complex and fragments in the nucleoplasm to release the viral genome.
