Viral reservoirs

Viral reservoirs are an anatomical site in which viruses accumulate and persist.

Latest Research and Reviews

  • Research |

    Dampened activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome in bat primary immune cells in response to infection with multiple zoonotic viruses is caused by decreased transcriptional priming, the presence of a unique splice variant and an altered leucine-rich repeat domain of bat NLRP3.

    • Matae Ahn
    • , Danielle E. Anderson
    • , Qian Zhang
    • , Chee Wah Tan
    • , Beng Lee Lim
    • , Katarina Luko
    • , Ming Wen
    • , Wan Ni Chia
    • , Shailendra Mani
    • , Loo Chien Wang
    • , Justin Han Jia Ng
    • , Radoslaw M. Sobota
    • , Charles-Antoine Dutertre
    • , Florent Ginhoux
    • , Zheng-Li Shi
    • , Aaron T. Irving
    •  & Lin-Fa Wang
    Nature Microbiology 4, 789-799
  • Research |

    An assay to measure the latent HIV-1 reservoir that separately quantifies intact and defective proviruses will facilitate evaluation of HIV-1 cure strategies by measuring the provirues that pose a barrier to cure.

    • Katherine M. Bruner
    • , Zheng Wang
    • , Francesco R. Simonetti
    • , Alexandra M. Bender
    • , Kyungyoon J. Kwon
    • , Srona Sengupta
    • , Emily J. Fray
    • , Subul A. Beg
    • , Annukka A. R. Antar
    • , Katharine M. Jenike
    • , Lynn N. Bertagnolli
    • , Adam A. Capoferri
    • , Joshua T. Kufera
    • , Andrew Timmons
    • , Christopher Nobles
    • , John Gregg
    • , Nikolas Wada
    • , Ya-Chi Ho
    • , Hao Zhang
    • , Joseph B. Margolick
    • , Joel N. Blankson
    • , Steven G. Deeks
    • , Frederic D. Bushman
    • , Janet D. Siliciano
    • , Gregory M. Laird
    •  & Robert F. Siliciano
    Nature 566, 120-125
  • Research |

    Měnglà virus (MLAV) is a phylogenetically distinct bat filovirus, whose genome shares 32–54% nucleotide sequence identity with known filoviruses. MLAV glycoprotein-typed pseudo-types can transduce cell lines derived from humans, monkeys, dogs, hamsters and bats.

    • Xing-Lou Yang
    • , Chee Wah Tan
    • , Danielle E. Anderson
    • , Ren-Di Jiang
    • , Bei Li
    • , Wei Zhang
    • , Yan Zhu
    • , Xiao Fang Lim
    • , Peng Zhou
    • , Xiang-Ling Liu
    • , Wuxiang Guan
    • , Libiao Zhang
    • , Shi-Yue Li
    • , Yun-Zhi Zhang
    • , Lin-Fa Wang
    •  & Zheng-Li Shi
    Nature Microbiology 4, 390-395
  • Reviews |

    Coronaviruses have a broad host range and distribution, and some highly pathogenic lineages have spilled over to humans and animals. Here, Cui, Li and Shi explore the viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome.

    • Jie Cui
    • , Fang Li
    •  & Zheng-Li Shi

News and Comment