Viral pathogenesis articles from across Nature Portfolio

Soil-borne wheat yellow mosaic virus (WYMV) poses a serious threat to global wheat production. Here, the authors report that the nuclear inclusion protease-a produced by WYMV interacts with a small peptide catalyzed by TaRD21A protease activity to mediate WYMV resistance through activating MAPK signaling pathway.

The neurovirulence determinants of Zika virus remain not fully established. Song et al identified a single K101R substitution in the capsid protein that contributes to the lineage-specific virulence phenotypes.

In this study, Han, Xu, and Wang et al. probe the diversity of bat coronaviruses (CoVs), revealing their evolutionary pattern with hosts. It underscores the evolutionary processes of CoVs, including SARS-CoV-2, and emphasizes the urgency of ongoing bat CoV surveillance.

Recovery and characterization of the wild-type pangolin coronavirus GD strain helps determine whether these viruses present risks for human transmission and an emerging threat to public health.

This study shows that intercellular long extensions promote the evasion of antibody neutralization and the efficient intercellular transmission of chikungunya virus in vitro and in vivo.

This study suggests that pre-existing DENV immunity has a negative effect on the pathogenesis of secondary ZIKV infection during pregnancy in marmosets.

This study reports a mechanism of norovirus-induced cell death that promotes viral egress.

This study shows that SARS-CoV-2 restructures host chromatin.

This work shows that Akkermansia muciniphila and its metabolite, harmaline, upregulate the production of bile acid-coenzyme A: amino acid N-acyltransferase (BAAT) in hepatocytes. As a result of enhanced BAAT production, increased synthesis of conjugated primary bile acids suppresses the severe systemic inflammation caused by severe fever with thrombocytopenia syndrome virus infection.