Viral pathogenesis

Viral pathogenesis is the process by which viruses infect and cause disease in a host.

Latest Research and Reviews

  • Research |

    Here, the authors identify lymphocyte antigen 6E (LY6E) as a coronavirus (CoV) restriction factor that prevents infection of B cells and dendritic cells. LY6E inhibits both human and mouse CoV entry into cells by interfering with viral spike protein-mediated membrane fusion. It facilitates an antiviral immune response that prevents liver disease and reduces death in the mouse model of MHV-A59 CoV infection.

    • Stephanie Pfaender
    • , Katrina B. Mar
    • , Eleftherios Michailidis
    • , Annika Kratzel
    • , Ian N. Boys
    • , Philip V’kovski
    • , Wenchun Fan
    • , Jenna N. Kelly
    • , Dagny Hirt
    • , Nadine Ebert
    • , Hanspeter Stalder
    • , Hannah Kleine-Weber
    • , Markus Hoffmann
    • , Hans-Heinrich Hoffmann
    • , Mohsan Saeed
    • , Ronald Dijkman
    • , Eike Steinmann
    • , Mary Wight-Carter
    • , Matthew B. McDougal
    • , Natasha W. Hanners
    • , Stefan Pöhlmann
    • , Tom Gallagher
    • , Daniel Todt
    • , Gert Zimmer
    • , Charles M. Rice
    • , John W. Schoggins
    •  & Volker Thiel
    Nature Microbiology 5, 1330-1339
  • Research |

    In this Article, the authors report the discovery of a small molecule (GHP-88309) that is a new class of allosteric viral polymerase inhibitor that works against two different genera of paramyxoviruses.

    • Robert M. Cox
    • , Julien Sourimant
    • , Mart Toots
    • , Jeong-Joong Yoon
    • , Satoshi Ikegame
    • , Mugunthan Govindarajan
    • , Ruth E. Watkinson
    • , Patricia Thibault
    • , Negar Makhsous
    • , Michelle J. Lin
    • , Jose R. Marengo
    • , Zachary Sticher
    • , Alexander A. Kolykhalov
    • , Michael G. Natchus
    • , Alexander L. Greninger
    • , Benhur Lee
    •  & Richard K. Plemper
    Nature Microbiology 5, 1232-1246
  • Research |

    The E3 ubiquitin ligase TRIM7 polyubiquitinates the envelope protein of Zika virus, adding Lys63-linked polyubiquitin chains that interact with the TIM1 receptor of host cells to enhance virus entry and replication.

    • Maria I. Giraldo
    • , Hongjie Xia
    • , Leopoldo Aguilera-Aguirre
    • , Adam Hage
    • , Sarah van Tol
    • , Chao Shan
    • , Xuping Xie
    • , Gail L. Sturdevant
    • , Shelly J. Robertson
    • , Kristin L. McNally
    • , Kimberly Meade-White
    • , Sasha R. Azar
    • , Shannan L. Rossi
    • , Wendy Maury
    • , Michael Woodson
    • , Holly Ramage
    • , Jeffrey R. Johnson
    • , Nevan J. Krogan
    • , Marc C. Morais
    • , Sonja M. Best
    • , Pei-Yong Shi
    •  & Ricardo Rajsbaum
    Nature 585, 414-419
  • Research
    | Open Access

    Here the authors show that a murine norovirus causes self-resolving diarrhea in the absence of systemic disease in wild-type neonatal mice and show that lymphocytes affect disease in a dual manner. The data suggests that neonatal mice are a promising model for further studies.

    • Alexa N. Roth
    • , Emily W. Helm
    • , Carmen Mirabelli
    • , Erin Kirsche
    • , Jonathan C. Smith
    • , Laura B. Eurell
    • , Sourish Ghosh
    • , Nihal Altan-Bonnet
    • , Christiane E. Wobus
    •  & Stephanie M. Karst
  • Research
    | Open Access

    Zika virus (ZIKV) infection of pregnant women is associated with pregnancy loss and birth defects, but molecular insights for the aetiology are scarce. Here the authors show that ZIKV reprograms the host lipidome to facilitate viral replication, induce mitochondria dysfunction, and cause immune imbalance, thereby identifying a potential target for ZIKV therapy.

    • Qian Chen
    • , Jordi Gouilly
    • , Yann J. Ferrat
    • , Ana Espino
    • , Quentin Glaziou
    • , Géraldine Cartron
    • , Hicham El Costa
    • , Reem Al-Daccak
    •  & Nabila Jabrane-Ferrat

News and Comment

  • Research Highlights |

    This study reports the identification and characterization of spindle-shaped viruses that infect a marine ammonia-oxidizing thaumarchaeon and that are distinct from other known marine viruses.

    • Andrea Du Toit
  • Comments and Opinion |

    The recent large outbreak of Ebola virus disease (EVD) in Western Africa resulted in greatly increased accumulation of human genotypic, phenotypic and clinical data, and improved our understanding of the spectrum of clinical manifestations. As a result, the WHO disease classification of EVD underwent major revision.

    • Jens H. Kuhn
    • , Takuya Adachi
    • , Neill K. J. Adhikari
    • , Jose R. Arribas
    • , Ibrahima Elhadj Bah
    • , Daniel G. Bausch
    • , Nahid Bhadelia
    • , Matthias Borchert
    • , Arne Broch Brantsæter
    • , David M. Brett-Major
    • , Timothy H. Burgess
    • , Daniel S. Chertow
    • , Christopher G. Chute
    • , Theodore J. Cieslak
    • , Robert Colebunders
    • , Ian Crozier
    • , Richard T. Davey
    • , Hilde de Clerck
    • , Rafael Delgado
    • , Laura Evans
    • , Mosoka Fallah
    • , William A. Fischer II
    • , Tom E. Fletcher
    • , Robert A. Fowler
    • , Thomas Grünewald
    • , Andy Hall
    • , Angela Hewlett
    • , Andy I. M. Hoepelman
    • , Catherine F. Houlihan
    • , Giuseppe Ippolito
    • , Shevin T. Jacob
    • , Michael Jacobs
    • , Robert Jakob
    • , Frederique A. Jacquerioz
    • , Laurent Kaiser
    • , Andre C. Kalil
    • , Rashidatu F. Kamara
    • , Jimmy Kapetshi
    • , Hans-Dieter Klenk
    • , Gary Kobinger
    • , Mark G. Kortepeter
    • , Colleen S. Kraft
    • , Thomas Kratz
    • , Henry S. Kyobe Bosa
    • , Marta Lado
    • , François Lamontagne
    • , H. Cliff Lane
    • , Leslie Lobel
    • , Julius Lutwama
    • , G. Marshall Lyon III
    • , Moses B. F. Massaquoi
    • , Thomas A. Massaquoi
    • , Aneesh K. Mehta
    • , Vital Mondonge Makuma
    • , Srinivas Murthy
    • , Tonny Seikikongo Musoke
    • , Jean-Jacques Muyembe-Tamfum
    • , Phiona Nakyeyune
    • , Carolina Nanclares
    • , Miriam Nanyunja
    • , Justus Nsio-Mbeta
    • , Tim O’Dempsey
    • , Janusz T. Pawęska
    • , Clarence J. Peters
    • , Peter Piot
    • , Christophe Rapp
    • , Bertrand Renaud
    • , Bruce Ribner
    • , Pardis C. Sabeti
    • , John S. Schieffelin
    • , Werner Slenczka
    • , Moses J. Soka
    • , Armand Sprecher
    • , James Strong
    • , Robert Swanepoel
    • , Timothy M. Uyeki
    • , Michel van Herp
    • , Pauline Vetter
    • , David A. Wohl
    • , Timo Wolf
    • , Anja Wolz
    • , Alie H. Wurie
    •  & Zabulon Yoti
  • Research Highlights |

    This study shows that naked and quasi-enveloped hepatitis A virus virions enter cells via similar endocytic pathways, but uncoating of capsids is temporally and spatially different.

    • Andrea du Toit