Vasculitis syndromes articles from across Nature Portfolio

A new study identifies proteinase 3 as an important driver of granuloma formation in granulomatosis with polyangiitis and points to potential therapeutic approaches.

An ambitious project to update the classification of vasculitis syndromes has culminated in the development of new classification criteria for anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, Takayasu arteritis and giant cell arteritis. Endorsed by the ACR and EULAR, the new criteria reflect progress in the understanding and assessment of these conditions.

Targeting inhibitor of apoptosis proteins (IAPs) ameliorates experimental ANCA-associated vasculitis, by enhancing fatty acid oxidation in neutrophils.

New classification criteria for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis endorsed by ACR and EULAR reflect important developments in the field since the 1990 criteria were published, including bringing ANCA testing to the fore.

The ACR have published their first guideline for the management of large vessel vasculitis, which covers giant cell arteritis and Takayasu arteritis. The new guideline differs from the current EULAR recommendations on some important points, but do these different views actually affect patient care?