Vascular diseases

Vascular diseases are pathological conditions affecting any of the blood vessels.

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Latest Research and Reviews

News and Comment

  • News and Views |

    New data highlight the contribution of IL-6 to vascular calcification in chronic inflammation. Given that increased vascular calcification and accelerated atherosclerosis occur in patients with chronic inflammatory diseases, new therapies that block the IL-6 pathway might reduce the risk of cardiovascular events in these patients.

    • Raquel López-Mejías
    •  & Miguel A. González-Gay
  • News and Views |

    A new trial has demonstrated the benefits of intravenous thrombolysis, guided by perfusion imaging, 4.5–9.0 h after stroke onset and in individuals with wake-up stroke. In addition to extending the time window for thrombolysis after acute ischaemic stroke, these findings could aid the refinement of imaging and thrombolytic protocols.

    • Min Lou
  • News and Views |

    The Global Burden of Disease, Injuries and Risk Factors 2016 study has shown that neurological diseases have the highest burden and that this burden is increasing. Stroke is the biggest contributor, highlighting a need to improve resources globally for stroke prevention, management and rehabilitation.

    • Ryuji Kaji
  • News and Views |

    A new study has demonstrated recovery of brain circulation and some cellular function in a decapitated pig model. Although these results are exciting and thought-provoking, they do not challenge the concept or practical implications of brain death, as no evidence of global electrical activity or functional recovery of the brain was presented.

    • David M. Greer
    •  & Ariane Lewis
  • Research Highlights |

    Neutrophils exacerbate tissue damage and inflammation in advanced atherosclerosis by triggering smooth muscle cell (SMC) lysis and death. Lesional neutrophils release neutrophil extracellular traps that contain histone H4, which interacts with SMCs to induce cell lysis, leading to the destabilization of atherosclerotic plaques.

    • Irene Fernández-Ruiz