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Aortic aneurysms have a heritable basis. Here, the authors report that a selenoprotein deficiency disorder due to mutations in SECISBP2, causes oxidative stress-mediated aortic cell death, predisposing to thoracic aortic aneurysm formation.
In patients with severe calcified aortic valve stenosis, treatment with transthoracically delivered non-invasive ultrasound is safe and improves valve function.
Tricuspid transcatheter edge-to-edge repair in patients with severe tricuspid regurgitation improved quality of life and reduced disease severity compared with medical therapy
In the Evolut Low Risk study, transcatheter aortic valve implantation in low-risk patients with severe aortic stenosis compared favourably with surgical aortic valve replacement in terms of all-cause mortality or disabling stroke at 3 years.
A body of experimental studies has pointed to a role for autoimmunity in atherosclerosis in animal models. Translational studies using single-cell sequencing now confirm that is also true of the atherosclerotic plaque development in humans.
