Urology

  • Article
    | Open Access

    Uropathogenic E. coli can adhere to vaginal epithelial cells preceding urinary tract infection (UTI). Here, Brannon et al. show that urinary E. coli isolates can not only adhere to, but also invade vaginal cells in mouse UTI models and in clinical samples obtained from women with recurrent UTI.

    • John R. Brannon
    • , Taryn L. Dunigan
    • , Connor J. Beebout
    • , Tamia Ross
    • , Michelle A. Wiebe
    • , William S. Reynolds
    •  & Maria Hadjifrangiskou
  • Article
    | Open Access

    Translocation renal cell carcinoma is an aggressive form of renal cancer that is often misdiagnosed to other subtypes. Here the authors demonstrated that by using machine learning and H&E stained whole-slide images, an accurate diagnose of this particular type of renal cancer can be achieved.

    • Jun Cheng
    • , Zhi Han
    • , Rohit Mehra
    • , Wei Shao
    • , Michael Cheng
    • , Qianjin Feng
    • , Dong Ni
    • , Kun Huang
    • , Liang Cheng
    •  & Jie Zhang
  • Article
    | Open Access

    Heterogeneous populations of basal cells in the prostate epithelium contain stem cells. Here the authors show that Zeb1 marks a pool of prostate epithelial stem cells that self-renew, generate prostate glandular structures with all 3 epithelial cell types and are required for prostate basal cell development.

    • Xue Wang
    • , Haibo Xu
    • , Chaping Cheng
    • , Zhongzhong Ji
    • , Huifang Zhao
    • , Yaru Sheng
    • , Xiaoxia Li
    • , Jinming Wang
    • , Yu Shu
    • , Yuman He
    • , Liancheng Fan
    • , Baijun Dong
    • , Wei Xue
    • , Chee Wai Chua
    • , Dongdong Wu
    • , Wei-Qiang Gao
    •  & Helen He Zhu
  • Article
    | Open Access

    The biology of the urothelium has been difficult to study given the lack of methods to propagate these cells. Here, the authors generate mouse urothelial organoids derived from bladder urothelial cells with high CD49f/ITGA6 and define what regulates urothelium differentiation, which is PPARγ, EGFR and Notch signalling.

    • Catarina P. Santos
    • , Eleonora Lapi
    • , Jaime Martínez de Villarreal
    • , Laura Álvaro-Espinosa
    • , Asunción Fernández-Barral
    • , Antonio Barbáchano
    • , Orlando Domínguez
    • , Ashley M. Laughney
    • , Diego Megías
    • , Alberto Muñoz
    •  & Francisco X. Real
  • Article
    | Open Access

    More than 170 genetic loci have been linked to prostate cancer risk, primarily based on genome-wide association studies (GWAS) in European population. Here, the authors performed a GWAS on a Japanese cohort of prostate cancer patients, finding 12 new susceptibility loci, and identifying a polygenic risk for Japanese prostate cancer.

    • Ryo Takata
    • , Atsushi Takahashi
    • , Masashi Fujita
    • , Yukihide Momozawa
    • , Edward J. Saunders
    • , Hiroki Yamada
    • , Kazuhiro Maejima
    • , Kaoru Nakano
    • , Yuichiro Nishida
    • , Asahi Hishida
    • , Keitaro Matsuo
    • , Kenji Wakai
    • , Taiki Yamaji
    • , Norie Sawada
    • , Motoki Iwasaki
    • , Shoichiro Tsugane
    • , Makoto Sasaki
    • , Atsushi Shimizu
    • , Kozo Tanno
    • , Naoko Minegishi
    • , Kichiya Suzuki
    • , Koichi Matsuda
    • , Michiaki Kubo
    • , Johji Inazawa
    • , Shin Egawa
    • , Christopher A. Haiman
    • , Osamu Ogawa
    • , Wataru Obara
    • , Yoichiro Kamatani
    • , Shusuke Akamatsu
    •  & Hidewaki Nakagawa
  • Article
    | Open Access

    Recurrent urinary tract infections occur in ~ 25% of women. Here, Beatson and colleagues use whole genome sequencing to track the dynamics of an E. coli ST131 clone in a single patient over a 5-year period. This study provides unique insights into pathogen evolution during recurrent urinary infection.

    • Brian M. Forde
    • , Leah W. Roberts
    • , Minh-Duy Phan
    • , Kate M. Peters
    • , Brittany A. Fleming
    • , Colin W. Russell
    • , Sara M. Lenherr
    • , Jeremy B. Myers
    • , Adam P. Barker
    • , Mark A. Fisher
    • , Teik-Min Chong
    • , Wai-Fong Yin
    • , Kok-Gan Chan
    • , Mark A. Schembri
    • , Matthew A. Mulvey
    •  & Scott A. Beatson
  • Article
    | Open Access

    In prostate cancer, investigating aberrant gene expression may shed light on disease etiology. Here, the authors imputed expression transcriptome-wide for 233,955 European ancestry men, discovering and replicating the associations between prostatic expression for select genes and prostate cancer risk, including the highly prevalent gene fusion partner TMPRSS2. The authors furthermore integrate diverse functional genomic datasets to interpret the epigenetic mechanisms by which the implicated risk variants and genes modulate disease risk.

    • Nima C. Emami
    • , Linda Kachuri
    • , Travis J. Meyers
    • , Rajdeep Das
    • , Joshua D. Hoffman
    • , Thomas J. Hoffmann
    • , Donglei Hu
    • , Jun Shan
    • , Felix Y. Feng
    • , Elad Ziv
    • , Stephen K. Van Den Eeden
    •  & John S. Witte
  • Article
    | Open Access

    The AR-V7 isoform is associated with anti-androgen drug resistance in prostate cancer. Here, the authors show that AR-V7 protein stability is regulated by HSP70/STUB1 complex-mediated proteostasis which confers drug resistance in late stage prostate cancer. Inhibition of HSP70 re-sensitizes resistant cells to enzalutamide therapy.

    • Chengfei Liu
    • , Wei Lou
    • , Joy C. Yang
    • , Liangren Liu
    • , Cameron M. Armstrong
    • , Alan P. Lombard
    • , Ruining Zhao
    • , Onika D. V. Noel
    • , Clifford G. Tepper
    • , Hong-Wu Chen
    • , Marc Dall’Era
    • , Christopher P. Evans
    •  & Allen C. Gao
  • Article
    | Open Access

    Urinary tract infections are one of the most common infections in humans. Here, the authors use urinary cell-free DNA (cfDNA) to comprehensively monitor host and pathogen dynamics in bacterial and viral urinary tract infections, and show that it is a versatile analyte for monitoring urinary tract infections.

    • Philip Burnham
    • , Darshana Dadhania
    • , Michael Heyang
    • , Fanny Chen
    • , Lars F. Westblade
    • , Manikkam Suthanthiran
    • , John Richard Lee
    •  & Iwijn De Vlaminck
  • Article
    | Open Access

    The female bladder seems to harbor a poorly characterized indigenous microbiota. Here, the authors isolate and genome-sequence 149 bacterial strains from catheterized urine of 77 women, generating a culture collection representing two thirds of the bacterial diversity within the samples.

    • Krystal Thomas-White
    • , Samuel C. Forster
    • , Nitin Kumar
    • , Michelle Van Kuiken
    • , Catherine Putonti
    • , Mark D. Stares
    • , Evann E. Hilt
    • , Travis K. Price
    • , Alan J. Wolfe
    •  & Trevor D. Lawley
  • Article
    | Open Access

    Treatment of prostate cancer, especially in its advanced stage, is still challenging; therefore, strategies to prevent metastatic dissemination are of great interest. Here the authors reveal a crucial role for liver X receptors in suppressing prostate carcinogenesis and metastatic progression in PTEN-null tumors.

    • Anthony Alioui
    • , Julie Dufour
    • , Valerio Leoni
    • , Anke Loregger
    • , Martina Moeton
    • , Luigi Iuliano
    • , Chiara Zerbinati
    • , Amandine Septier
    • , Pierre Val
    • , Allan Fouache
    • , Vincenzo Russo
    • , David H. Volle
    • , Jean-Marc A. Lobaccaro
    • , Noam Zelcer
    •  & Silvère Baron