Urology

  • Article | | open

    Bladder cancer is one of the most common and highly vascularized cancers. Here the authors perform a whole-genome analysis in urothelial bladder carcinomas and identify recurrent genetic alterations in a set of angiogenesis genes, facilitating the understanding of molecular mechanisms underlying pathological angiogenesis in this type of cancer.

    • Song Wu
    • , Tong Ou
    • , Nianzeng Xing
    • , Jiang Lu
    • , Shengqing Wan
    • , Changxi Wang
    • , Xi Zhang
    • , Feiya Yang
    • , Yi Huang
    •  & Zhiming Cai
  • Article | | open

    ER stress and UPR are implicated in various cancers. Here, the authors show that one of the canonical UPR pathways, IRE1α-XBP1 regulates c-MYC signaling to promote prostate tumorigenesis, and pharmacological inhibition of IRE1α with MKC8866 inhibits prostate cancer growth and synergizes with clinically used prostate cancer drugs.

    • Xia Sheng
    • , Hatice Zeynep Nenseth
    • , Su Qu
    • , Omer F. Kuzu
    • , Turid Frahnow
    • , Lukas Simon
    • , Stephanie Greene
    • , Qingping Zeng
    • , Ladan Fazli
    • , Paul S. Rennie
    • , Ian G. Mills
    • , Håvard Danielsen
    • , Fabian Theis
    • , John B. Patterson
    • , Yang Jin
    •  & Fahri Saatcioglu
  • Article | | open

    miR-205 is known to have context-dependent tumor suppressive or oncogenic roles. Here, the authors report the host gene of miR-205, MIR205HG as a nuclear lincRNA that maintains the basal identity of prostate cell and prevents luminal cell differentiation via the repression of interferon responsive genes.

    • Valentina Profumo
    • , Barbara Forte
    • , Stefano Percio
    • , Federica Rotundo
    • , Valentina Doldi
    • , Elena Ferrari
    • , Nicola Fenderico
    • , Matteo Dugo
    • , Dario Romagnoli
    • , Matteo Benelli
    • , Riccardo Valdagni
    • , Diletta Dolfini
    • , Nadia Zaffaroni
    •  & Paolo Gandellini
  • Article | | open

    Neuroendocrine prostate cancer (NEPC) is characterized by loss of androgen receptor (AR) signaling during neuroendocrine transdifferentiation, resulting in resistance to AR-targeted therapy. Here they report ONECUT2 to drive NEPC tumorigenesis via regulation of hypoxia signaling and tumor hypoxia, and find hypoxia directed therapy to be effective in NEPC.

    • Haiyang Guo
    • , Xinpei Ci
    • , Musaddeque Ahmed
    • , Junjie Tony Hua
    • , Fraser Soares
    • , Dong Lin
    • , Loredana Puca
    • , Aram Vosoughi
    • , Hui Xue
    • , Estelle Li
    • , Peiran Su
    • , Sujun Chen
    • , Tran Nguyen
    • , Yi Liang
    • , Yuzhe Zhang
    • , Xin Xu
    • , Jing Xu
    • , Anjali V. Sheahan
    • , Wail Ba-Alawi
    • , Si Zhang
    • , Osman Mahamud
    • , Ravi N. Vellanki
    • , Martin Gleave
    • , Robert G. Bristow
    • , Benjamin Haibe-Kains
    • , John T. Poirier
    • , Charles M. Rudin
    • , Ming-Sound Tsao
    • , Bradly G. Wouters
    • , Ladan Fazli
    • , Felix Y. Feng
    • , Leigh Ellis
    • , Theo van der Kwast
    • , Alejandro Berlin
    • , Marianne Koritzinsky
    • , Paul C. Boutros
    • , Amina Zoubeidi
    • , Himisha Beltran
    • , Yuzhuo Wang
    •  & Housheng Hansen He
  • Article | | open

    Activation of the PPARγ/RXRα pathway in luminal bladder cancers has mainly been linked to PPARG gene amplifications and activating point mutations in RXRα. Here, the authors identify recurrent PPARγ mutations with similar effects and elucidate the structural basis for this mutational PPARγ activation.

    • Natacha Rochel
    • , Clémentine Krucker
    • , Laure Coutos-Thévenot
    • , Judit Osz
    • , Ruiyun Zhang
    • , Elodie Guyon
    • , Wayne Zita
    • , Séverin Vanthong
    • , Oscar Alba Hernandez
    • , Maxime Bourguet
    • , Kays Al Badawy
    • , Florent Dufour
    • , Carole Peluso-Iltis
    • , Syrine Heckler-Beji
    • , Annick Dejaegere
    • , Aurélie Kamoun
    • , Aurélien de Reyniès
    • , Yann Neuzillet
    • , Sandra Rebouissou
    • , Claire Béraud
    • , Hervé Lang
    • , Thierry Massfelder
    • , Yves Allory
    • , Sarah Cianférani
    • , Roland H. Stote
    • , François Radvanyi
    •  & Isabelle Bernard-Pierrot
  • Article | | open

    Identifying cell intrinsic mechanisms promoting metastasis are necessary to develop new cancer therapeutics. Here they do cross-species computational analysis and identify nuclear receptor binding SET domain Protein 2 (NSD2) as a driver of prostate cancer metastasis.

    • Alvaro Aytes
    • , Arianna Giacobbe
    • , Antonina Mitrofanova
    • , Katia Ruggero
    • , Joanna Cyrta
    • , Juan Arriaga
    • , Luis Palomero
    • , Sonia Farran-Matas
    • , Mark A. Rubin
    • , Michael M. Shen
    • , Andrea Califano
    •  & Cory Abate-Shen
  • Article | | open

    TRIM24 is stabilized in SPOP-mutated prostate cancers, but the regulation of TRIM24 in wild-type prostate cancers is unknown. Here, the authors show that TRIM28 interacts with TRIM24 to prevent SPOP-mediated ubiquitination of TRIM24 and enhances TRIM24 and AR signaling to induce prostate cancer tumorigenesis.

    • Ka-wing Fong
    • , Jonathan C. Zhao
    • , Bing Song
    • , Bin Zheng
    •  & Jindan Yu
  • Article | | open

    Prostate cancer often develops resistance to androgen receptor (AR) targeting drugs. Here, the authors show that, under conditions of hypoxia, AR inhibition via enzalutamide increases the expression of the glycolytic enzyme phosphoglucose isomerase (GPI) promoting a metabolic rewiring that allows the cells to survive, and consistent GPI inhibition restores sensitivity to enzalutamide.

    • Hao Geng
    • , Changhui Xue
    • , Janet Mendonca
    • , Xiao-Xin Sun
    • , Qiong Liu
    • , Patrick N. Reardon
    • , Yingxiao Chen
    • , Kendrick Qian
    • , Vivian Hua
    • , Alice Chen
    • , Freddy Pan
    • , Julia Yuan
    • , Sang Dang
    • , Tomasz M. Beer
    • , Mu-Shui Dai
    • , Sushant K. Kachhap
    •  & David Z. Qian
  • Article | | open

    The Androgen Receptor (AR) is the main driver of prostate cancer and functions in conjunction with chromatin modifications. Here, the authors comprehensively profile 100 primary prostate carcinomas by sequencing RNA transcripts in combination with ChIP-sequencing for AR and the active histone marks H3K27ac, H3K4me3 and repressive mark H3K27me3.

    • Suzan Stelloo
    • , Ekaterina Nevedomskaya
    • , Yongsoo Kim
    • , Karianne Schuurman
    • , Eider Valle-Encinas
    • , João Lobo
    • , Oscar Krijgsman
    • , Daniel Simon Peeper
    • , Seiwon Laura Chang
    • , Felix Yi-Chung Feng
    • , Lodewyk Frederik Ary Wessels
    • , Rui Henrique
    • , Carmen Jerónimo
    • , Andries Marinus Bergman
    •  & Wilbert Zwart
  • Article | | open

    The AR-V7 isoform is associated with anti-androgen drug resistance in prostate cancer. Here, the authors show that AR-V7 protein stability is regulated by HSP70/STUB1 complex-mediated proteostasis which confers drug resistance in late stage prostate cancer. Inhibition of HSP70 re-sensitizes resistant cells to enzalutamide therapy.

    • Chengfei Liu
    • , Wei Lou
    • , Joy C. Yang
    • , Liangren Liu
    • , Cameron M. Armstrong
    • , Alan P. Lombard
    • , Ruining Zhao
    • , Onika D. V. Noel
    • , Clifford G. Tepper
    • , Hong-Wu Chen
    • , Marc Dall’Era
    • , Christopher P. Evans
    •  & Allen C. Gao
  • Article | | open

    Neuroendocrine prostate cancers are very difficult to treat and often arise after androgen-deprivation therapy. Here the authors show that ADT activates CREB that acts by increasing EZH2 activity to promote neuroendocrine differentiation in prostate cancer, providing alternative avenues for therapy.

    • Yan Zhang
    • , Dayong Zheng
    • , Ting Zhou
    • , Haiping Song
    • , Mohit Hulsurkar
    • , Ning Su
    • , Ying Liu
    • , Zheng Wang
    • , Long Shao
    • , Michael Ittmann
    • , Martin Gleave
    • , Huanxing Han
    • , Feng Xu
    • , Wangjun Liao
    • , Hongbo Wang
    •  & Wenliang Li
  • Article | | open

    The functional significance of the observed heterogeneity of androgen receptor (AR) expression in prostate cancer is unknown. Here the authors show AR expression heterogeneity is associated with distinct castration/enzalutamide responses and identify BCL-2 as a potential therapeutic target in castration-resistant prostate cancer.

    • Qiuhui Li
    • , Qu Deng
    • , Hsueh-Ping Chao
    • , Xin Liu
    • , Yue Lu
    • , Kevin Lin
    • , Bigang Liu
    • , Gregory W. Tang
    • , Dingxiao Zhang
    • , Amanda Tracz
    • , Collene Jeter
    • , Kiera Rycaj
    • , Tammy Calhoun-Davis
    • , Jiaoti Huang
    • , Mark A. Rubin
    • , Himisha Beltran
    • , Jianjun Shen
    • , Gurkamal Chatta
    • , Igor Puzanov
    • , James L. Mohler
    • , Jianmin Wang
    • , Ruizhe Zhao
    • , Jason Kirk
    • , Xin Chen
    •  & Dean G. Tang
  • Article | | open

    Urinary tract infections are one of the most common infections in humans. Here, the authors use urinary cell-free DNA (cfDNA) to comprehensively monitor host and pathogen dynamics in bacterial and viral urinary tract infections, and show that it is a versatile analyte for monitoring urinary tract infections.

    • Philip Burnham
    • , Darshana Dadhania
    • , Michael Heyang
    • , Fanny Chen
    • , Lars F. Westblade
    • , Manikkam Suthanthiran
    • , John Richard Lee
    •  & Iwijn De Vlaminck
  • Article | | open

    Prostate cancer (PrCa) involves a large heritable genetic component. Here, the authors perform multivariate fine-mapping of known PrCa GWAS loci, identifying variants enriched for biological function, explaining more familial relative risk, and with potential application in clinical risk profiling.

    • Tokhir Dadaev
    • , Edward J. Saunders
    • , Paul J. Newcombe
    • , Ezequiel Anokian
    • , Daniel A. Leongamornlert
    • , Mark N. Brook
    • , Clara Cieza-Borrella
    • , Martina Mijuskovic
    • , Sarah Wakerell
    • , Ali Amin Al Olama
    • , Fredrick R. Schumacher
    • , Sonja I. Berndt
    • , Sara Benlloch
    • , Mahbubl Ahmed
    • , Chee Goh
    • , Xin Sheng
    • , Zhuo Zhang
    • , Kenneth Muir
    • , Koveela Govindasami
    • , Artitaya Lophatananon
    • , Victoria L. Stevens
    • , Susan M. Gapstur
    • , Brian D. Carter
    • , Catherine M. Tangen
    • , Phyllis Goodman
    • , Ian M. Thompson Jr.
    • , Jyotsna Batra
    • , Suzanne Chambers
    • , Leire Moya
    • , Judith Clements
    • , Lisa Horvath
    • , Wayne Tilley
    • , Gail Risbridger
    • , Henrik Gronberg
    • , Markus Aly
    • , Tobias Nordström
    • , Paul Pharoah
    • , Nora Pashayan
    • , Johanna Schleutker
    • , Teuvo L. J. Tammela
    • , Csilla Sipeky
    • , Anssi Auvinen
    • , Demetrius Albanes
    • , Stephanie Weinstein
    • , Alicja Wolk
    • , Niclas Hakansson
    • , Catharine West
    • , Alison M. Dunning
    • , Neil Burnet
    • , Lorelei Mucci
    • , Edward Giovannucci
    • , Gerald Andriole
    • , Olivier Cussenot
    • , Géraldine Cancel-Tassin
    • , Stella Koutros
    • , Laura E. Beane Freeman
    • , Karina Dalsgaard Sorensen
    • , Torben Falck Orntoft
    • , Michael Borre
    • , Lovise Maehle
    • , Eli Marie Grindedal
    • , David E. Neal
    • , Jenny L. Donovan
    • , Freddie C. Hamdy
    • , Richard M. Martin
    • , Ruth C. Travis
    • , Tim J. Key
    • , Robert J. Hamilton
    • , Neil E. Fleshner
    • , Antonio Finelli
    • , Sue Ann Ingles
    • , Mariana C. Stern
    • , Barry Rosenstein
    • , Sarah Kerns
    • , Harry Ostrer
    • , Yong-Jie Lu
    • , Hong-Wei Zhang
    • , Ninghan Feng
    • , Xueying Mao
    • , Xin Guo
    • , Guomin Wang
    • , Zan Sun
    • , Graham G. Giles
    • , Melissa C. Southey
    • , Robert J. MacInnis
    • , Liesel M. FitzGerald
    • , Adam S. Kibel
    • , Bettina F. Drake
    • , Ana Vega
    • , Antonio Gómez-Caamaño
    • , Laura Fachal
    • , Robert Szulkin
    • , Martin Eklund
    • , Manolis Kogevinas
    • , Javier Llorca
    • , Gemma Castaño-Vinyals
    • , Kathryn L. Penney
    • , Meir Stampfer
    • , Jong Y. Park
    • , Thomas A. Sellers
    • , Hui-Yi Lin
    • , Janet L. Stanford
    • , Cezary Cybulski
    • , Dominika Wokolorczyk
    • , Jan Lubinski
    • , Elaine A. Ostrander
    • , Milan S. Geybels
    • , Børge G. Nordestgaard
    • , Sune F. Nielsen
    • , Maren Weisher
    • , Rasmus Bisbjerg
    • , Martin Andreas Røder
    • , Peter Iversen
    • , Hermann Brenner
    • , Katarina Cuk
    • , Bernd Holleczek
    • , Christiane Maier
    • , Manuel Luedeke
    • , Thomas Schnoeller
    • , Jeri Kim
    • , Christopher J. Logothetis
    • , Esther M. John
    • , Manuel R. Teixeira
    • , Paula Paulo
    • , Marta Cardoso
    • , Susan L. Neuhausen
    • , Linda Steele
    • , Yuan Chun Ding
    • , Kim De Ruyck
    • , Gert De Meerleer
    • , Piet Ost
    • , Azad Razack
    • , Jasmine Lim
    • , Soo-Hwang Teo
    • , Daniel W. Lin
    • , Lisa F. Newcomb
    • , Davor Lessel
    • , Marija Gamulin
    • , Tomislav Kulis
    • , Radka Kaneva
    • , Nawaid Usmani
    • , Chavdar Slavov
    • , Vanio Mitev
    • , Matthew Parliament
    • , Sandeep Singhal
    • , Frank Claessens
    • , Steven Joniau
    • , Thomas Van den Broeck
    • , Samantha Larkin
    • , Paul A. Townsend
    • , Claire Aukim-Hastie
    • , Manuela Gago-Dominguez
    • , Jose Esteban Castelao
    • , Maria Elena Martinez
    • , Monique J. Roobol
    • , Guido Jenster
    • , Ron H. N. van Schaik
    • , Florence Menegaux
    • , Thérèse Truong
    • , Yves Akoli Koudou
    • , Jianfeng Xu
    • , Kay-Tee Khaw
    • , Lisa Cannon-Albright
    • , Hardev Pandha
    • , Agnieszka Michael
    • , Andrzej Kierzek
    • , Stephen N. Thibodeau
    • , Shannon K. McDonnell
    • , Daniel J. Schaid
    • , Sara Lindstrom
    • , Constance Turman
    • , Jing Ma
    • , David J. Hunter
    • , Elio Riboli
    • , Afshan Siddiq
    • , Federico Canzian
    • , Laurence N. Kolonel
    • , Loic Le Marchand
    • , Robert N. Hoover
    • , Mitchell J. Machiela
    • , Peter Kraft
    • , Margaret Cook
    • , Alison Thwaites
    • , Michelle Guy
    • , Ian Whitmore
    • , Angela Morgan
    • , Cyril Fisher
    • , Steve Hazel
    • , Naomi Livni
    • , Amanda Spurdle
    • , Srilakshmi Srinivasan
    • , Mary-Anne Kedda
    • , Joanne Aitken
    • , Robert Gardiner
    • , Vanessa Hayes
    • , Lisa Butler
    • , Renea Taylor
    • , Trina Yeadon
    • , Allison Eckert
    • , Pamela Saunders
    • , Anne-Maree Haynes
    • , Melissa Papargiris
    • , Paula Kujala
    • , Kirsi Talala
    • , Teemu Murtola
    • , Kimmo Taari
    • , David Dearnaley
    • , Gill Barnett
    • , Søren Bentzen
    • , Rebecca Elliott
    • , Hardeep Ranu
    • , Belynda Hicks
    • , Aurelie Vogt
    • , Amy Hutchinson
    • , Angela Cox
    • , Michael Davis
    • , Paul Brown
    • , Anne George
    • , Gemma Marsden
    • , Athene Lane
    • , Sarah J. Lewis
    • , Clare Berry
    • , Girish S. Kulkarni
    • , Ants Toi
    • , Andrew Evans
    • , Alexandre R. Zlotta
    • , Theodorus H. van der Kwast
    • , Takashi Imai
    • , Shiro Saito
    • , Jacek Marzec
    • , Guangwen Cao
    • , Ji Lin
    • , Jin Ling
    • , Meiling Li
    • , Shan-Chao Zhao
    • , Guoping Ren
    • , Yongwei Yu
    • , Yudong Wu
    • , Ji Wu
    • , Bo Zhou
    • , Yangling Zhang
    • , Jie Li
    • , Weiyang He
    • , Jianming Guo
    • , John Pedersen
    • , John L. Hopper
    • , Roger Milne
    • , Aleksandra Klim
    • , Ana Carballo
    • , Ramón Lobato-Busto
    • , Paula Peleteiro
    • , Patricia Calvo
    • , Miguel Aguado
    • , José Manuel Ruiz-Dominguez
    • , Lluís Cecchini
    • , Lourdes Mengual
    • , Antonio Alcaraz
    • , Mariona Bustamante
    • , Esther Gracia-Lavedan
    • , Trinidad Dierssen-Sotos
    • , Ines Gomez-Acebo
    • , Julio Pow-Sang
    • , Hyun Park
    • , Babu Zachariah
    • , Wojciech Kluzniak
    • , Suzanne Kolb
    • , Peter Klarskov
    • , Christa Stegmaier
    • , Walther Vogel
    • , Kathleen Herkommer
    • , Philipp Bohnert
    • , Sofia Maia
    • , Maria P. Silva
    • , Sofie De Langhe
    • , Hubert Thierens
    • , Meng H. Tan
    • , Aik T. Ong
    • , Zeljko Kastelan
    • , Elenko Popov
    • , Darina Kachakova
    • , Atanaska Mitkova
    • , Aleksandrina Vlahova
    • , Tihomir Dikov
    • , Svetlana Christova
    • , Angel Carracedo
    • , Christopher Bangma
    • , F. H. Schroder
    • , Sylvie Cenee
    • , Brigitte Tretarre
    • , Xavier Rebillard
    • , Claire Mulot
    • , Marie Sanchez
    • , Jan Adolfsson
    • , Par Stattin
    • , Jan-Erik Johansson
    • , Carin Cavalli-Bjoerkman
    • , Ami Karlsson
    • , Michael Broms
    • , Huihai Wu
    • , Lori Tillmans
    • , Shaun Riska
    • , Matthew Freedman
    • , Fredrik Wiklund
    • , Stephen Chanock
    • , Brian E. Henderson
    • , Douglas F. Easton
    • , Christopher A. Haiman
    • , Rosalind A. Eeles
    • , David V. Conti
    •  & Zsofia Kote-Jarai
  • Article | | open

    Wnt11 has been shown to play a role in invasion and metastasis of prostate cancer. Here the authors show that in prostate cancer cells Wnt11 signals through the Fzd8 receptor and report an interaction between Fzd8 and TGF-β receptors regulating the transcription of a subset of TGF-beta genes.

    • Virginia Murillo-Garzón
    • , Irantzu Gorroño-Etxebarria
    • , Malin Åkerfelt
    • , Mikael Christer Puustinen
    • , Lea Sistonen
    • , Matthias Nees
    • , James Carton
    • , Jonathan Waxman
    •  & Robert M. Kypta
  • Article | | open

    Radionuclides that emit alpha particles (charged helium nuclei) are currently used clinically to treat cancers including prostate cancer. Here, the authors combine a humanized antibody to an alpha particle emitter, specifically to target a downstream effector of the androgen receptor and create a feed forward loop that increases the therapeutic efficacy.

    • Michael R. McDevitt
    • , Daniel L. J. Thorek
    • , Takeshi Hashimoto
    • , Tatsuo Gondo
    • , Darren R. Veach
    • , Sai Kiran Sharma
    • , Teja Muralidhar Kalidindi
    • , Diane S. Abou
    • , Philip A. Watson
    • , Bradley J. Beattie
    • , Oskar Vilhemsson Timmermand
    • , Sven-Erik Strand
    • , Jason S. Lewis
    • , Peter T. Scardino
    • , Howard I. Scher
    • , Hans Lilja
    • , Steven M. Larson
    •  & David Ulmert
  • Article | | open

    CP1 is an uropathogenic Escherichia coli previously shown to promote inflammation and progression to prostate cancer. Here the authors show that in the context of a fully developed prostate cancer, CP1 promotes T cell infiltration into the tumour and increases the efficacy of anti-PD1 immunotherapy.

    • Jonathan F. Anker
    • , Anum F. Naseem
    • , Hanlin Mok
    • , Anthony J. Schaeffer
    • , Sarki A. Abdulkadir
    •  & Praveen Thumbikat
  • Article | | open

    The female bladder seems to harbor a poorly characterized indigenous microbiota. Here, the authors isolate and genome-sequence 149 bacterial strains from catheterized urine of 77 women, generating a culture collection representing two thirds of the bacterial diversity within the samples.

    • Krystal Thomas-White
    • , Samuel C. Forster
    • , Nitin Kumar
    • , Michelle Van Kuiken
    • , Catherine Putonti
    • , Mark D. Stares
    • , Evann E. Hilt
    • , Travis K. Price
    • , Alan J. Wolfe
    •  & Trevor D. Lawley
  • Article | | open

    Understanding of molecular events in cancer requires proteome-level characterisation. Here, proteome profiling of patient samples representing primary and progressed prostate cancer enables the authors to identify pathway alterations that are not reflected at the genomic and transcriptomic levels.

    • Leena Latonen
    • , Ebrahim Afyounian
    • , Antti Jylhä
    • , Janika Nättinen
    • , Ulla Aapola
    • , Matti Annala
    • , Kati K. Kivinummi
    • , Teuvo T. L. Tammela
    • , Roger W. Beuerman
    • , Hannu Uusitalo
    • , Matti Nykter
    •  & Tapio Visakorpi
  • Article | | open

    Asthenozoospermia is a major cause of male infertility, and multiple morphological abnormalities of the flagella (MMAF) is a particularly severe form. Here, using whole-exome sequencing of 78 MMAF patients, the authors identify mutations in two WDR proteins, CFAP43 and CFAP44, and confirm that these proteins are required for flagellogenesis in mouse and Trypanosoma brucei.

    • Charles Coutton
    • , Alexandra S. Vargas
    • , Amir Amiri-Yekta
    • , Zine-Eddine Kherraf
    • , Selima Fourati Ben Mustapha
    • , Pauline Le Tanno
    • , Clémentine Wambergue-Legrand
    • , Thomas Karaouzène
    • , Guillaume Martinez
    • , Serge Crouzy
    • , Abbas Daneshipour
    • , Seyedeh Hanieh Hosseini
    • , Valérie Mitchell
    • , Lazhar Halouani
    • , Ouafi Marrakchi
    • , Mounir Makni
    • , Habib Latrous
    • , Mahmoud Kharouf
    • , Jean-François Deleuze
    • , Anne Boland
    • , Sylviane Hennebicq
    • , Véronique Satre
    • , Pierre-Simon Jouk
    • , Nicolas Thierry-Mieg
    • , Beatrice Conne
    • , Denis Dacheux
    • , Nicolas Landrein
    • , Alain Schmitt
    • , Laurence Stouvenel
    • , Patrick Lorès
    • , Elma El Khouri
    • , Serge P. Bottari
    • , Julien Fauré
    • , Jean-Philippe Wolf
    • , Karin Pernet-Gallay
    • , Jessica Escoffier
    • , Hamid Gourabi
    • , Derrick R. Robinson
    • , Serge Nef
    • , Emmanuel Dulioust
    • , Raoudha Zouari
    • , Mélanie Bonhivers
    • , Aminata Touré
    • , Christophe Arnoult
    •  & Pierre F. Ray
  • Article | | open

    The polycomb group protein BMI1 is highly expressed in prostate cancer. Here, the authors demonstrate that BMI1 directly interacts with AR leading to increased AR signaling independently of PRC1 complex and that targeting BMI1 inhibits tumor growth of castration-resistant prostate cancer tumors.

    • Sen Zhu
    • , Dongyu Zhao
    • , Lin Yan
    • , Weihua Jiang
    • , Jung-Sun Kim
    • , Bingnan Gu
    • , Qipeng Liu
    • , Rui Wang
    • , Bo Xia
    • , Jonathan C. Zhao
    • , Gang Song
    • , Wenyi Mi
    • , Rong-Fu Wang
    • , Xiaobing Shi
    • , Hung-Ming Lam
    • , Xuesen Dong
    • , Jindan Yu
    • , Kaifu Chen
    •  & Qi Cao
  • Article | | open

    Alterations in the MAPK pathway are common in cancers, yet mutations are rarely found in patients. Here the authors find genomic amplifications of the PPP1CA gene in advanced and metastatic prostate cancer and identify a role for this phosphatase in the positive regulation of ERK signalling.

    • Ming Chen
    • , Lixin Wan
    • , Jiangwen Zhang
    • , Jinfang Zhang
    • , Lourdes Mendez
    • , John G. Clohessy
    • , Kelsey Berry
    • , Joshua Victor
    • , Qing Yin
    • , Yuan Zhu
    • , Wenyi Wei
    •  & Pier Paolo Pandolfi
  • Article | | open

    The impact of cisplatin-based chemotherapy on tumor genomes is complex. Here, the authors study matched pre- and post-chemotherapy primary samples in muscle-invasive bladder cancer, finding a cisplatin-based mutational signature, and highlighting the impact of intratumor heterogeneity on survival.

    • David Liu
    • , Philip Abbosh
    • , Daniel Keliher
    • , Brendan Reardon
    • , Diana Miao
    • , Kent Mouw
    • , Amaro Weiner-Taylor
    • , Stephanie Wankowicz
    • , Garam Han
    • , Min Yuen Teo
    • , Catharine Cipolla
    • , Jaegil Kim
    • , Gopa Iyer
    • , Hikmat Al-Ahmadie
    • , Essel Dulaimi
    • , David Y. T. Chen
    • , R. Katherine Alpaugh
    • , Jean Hoffman-Censits
    • , Levi A. Garraway
    • , Gad Getz
    • , Scott L. Carter
    • , Joaquim Bellmunt
    • , Elizabeth R. Plimack
    • , Jonathan E. Rosenberg
    •  & Eliezer M. Van Allen
  • Article | | open

    Mutations in VHL have been linked to clear cell renal cancer, but the molecular mechanisms involved remain unclear. Here the authors generate a mouse model closely mimicking the human disease and show that VHL loss induces DNA replication stress that is rescued by the concomitant loss of PBRM1 permitting transformation.

    • Judit Espana-Agusti
    • , Anne Warren
    • , Su Kit Chew
    • , David J. Adams
    •  & Athena Matakidou
  • Article | | open

    Cell-based hormone replacement therapy (cHRT) may be an alternative therapy to pharmacological (p)HRT. Here, the authors show that implanted 3D bioengineered ovarian constructs of granulosa and theca cells in ovariectomized rats recapitulate native cell interactions and improve efficacy compared to similar doses of pHRT.

    • Sivanandane Sittadjody
    • , Justin M. Saul
    • , John P. McQuilling
    • , Sunyoung Joo
    • , Thomas C. Register
    • , James J. Yoo
    • , Anthony Atala
    •  & Emmanuel C. Opara
  • Article | | open

    Clear cell renal cancers (ccRCC) display elevated intracellular lipid storage. Here the authors show that such lipid accumulation is due to the repression of carnitine palmitoyltransferase 1A (CPT1A) enzyme that impairs fatty acid (FA) transport into the mitochondrion resulting in reduced FA beta oxidation.

    • Weinan Du
    • , Luchang Zhang
    • , Adina Brett-Morris
    • , Brittany Aguila
    • , Janos Kerner
    • , Charles L. Hoppel
    • , Michelle Puchowicz
    • , Dolors Serra
    • , Laura Herrero
    • , Brian I. Rini
    • , Steven Campbell
    •  & Scott M. Welford
  • Article | | open

    Renal angiomyolipomas (AML) contain a mix of clonal tumour cells. Here, through reverse tumour engineering experiments, mouse genetics and analyses of human AML tumours, the authors provide evidence that these mesenchymal tumours originate from renal proximal tubule epithelial cells.

    • Ana Filipa Gonçalves
    • , Mojca Adlesic
    • , Simone Brandt
    • , Tomas Hejhal
    • , Sabine Harlander
    • , Lukas Sommer
    • , Olga Shakhova
    • , Peter J. Wild
    •  & Ian J. Frew
  • Article | | open

    Acetylation of the histone variant H2A.Z at gene promoters is associated with oncogene activation; however, it is unclear if such modification has a role in regulating the function of enhancers. Here the authors show that acetylated H2A.Z is redistributed at cancer neo-enhancers and regulates the activity of specific enhancers of cancer-related genes.

    • Fátima Valdés-Mora
    • , Cathryn M. Gould
    • , Yolanda Colino-Sanguino
    • , Wenjia Qu
    • , Jenny Z. Song
    • , Kylie M. Taylor
    • , Fabian A. Buske
    • , Aaron L. Statham
    • , Shalima S. Nair
    • , Nicola J. Armstrong
    • , James G. Kench
    • , Kenneth M. L. Lee
    • , Lisa G. Horvath
    • , Minru Qiu
    • , Alexei Ilinykh
    • , Nicole S. Yeo-Teh
    • , David Gallego-Ortega
    • , Clare Stirzaker
    •  & Susan J. Clark
  • Article | | open

    Identifying actionable components in castration–resistant prostate cancer (CRPC) is critical for the development of effective treatments. Here, the authors show that the inhibition of the redox-protective protein TRX1 decreases the growth of CRPC cells through the regulation of ROS levels, p53 and androgen receptor expression.

    • Govindi J. Samaranayake
    • , Clara I. Troccoli
    • , Mai Huynh
    • , Rolando D. Z. Lyles
    • , Karen Kage
    • , Andrew Win
    • , Vishalakshi Lakshmanan
    • , Deukwoo Kwon
    • , Yuguang Ban
    • , Steven Xi Chen
    • , Enrique Rodriguez Zarco
    • , Merce Jorda
    • , Kerry L. Burnstein
    •  & Priyamvada Rai
  • Article | | open

    The incidence of renal cell carcinoma is higher in males than in females due to the different androgen receptor signaling but the molecular mechanisms behind this gender bias are unclear. Here the authors show how androgen receptor expression influences the metastatic route through the regulation of miR-185 and VEGF isoforms.

    • Qingbo Huang
    • , Yin Sun
    • , Xin Ma
    • , Yu Gao
    • , Xintao Li
    • , Yuanjie Niu
    • , Xu Zhang
    •  & Chawnshang Chang
  • Article | | open

    In prostate cancer, the role of mutations in the maternally-inherited mitochondrial genome are not well known. Here, the authors demonstrate frequent, age-dependent mitochondrial mutation in prostate cancer. Strong links between mitochondrial and nuclear mutational profiles are associated with clinical aggressivity.

    • Julia F. Hopkins
    • , Veronica Y. Sabelnykova
    • , Joachim Weischenfeldt
    • , Ronald Simon
    • , Jennifer A. Aguiar
    • , Rached Alkallas
    • , Lawrence E. Heisler
    • , Junyan Zhang
    • , John D. Watson
    • , Melvin L. K. Chua
    • , Michael Fraser
    • , Francesco Favero
    • , Chris Lawerenz
    • , Christoph Plass
    • , Guido Sauter
    • , John D. McPherson
    • , Theodorus van der Kwast
    • , Jan Korbel
    • , Thorsten Schlomm
    • , Robert G. Bristow
    •  & Paul C. Boutros
  • Article | | open

    Treatment of prostate cancer, especially in its advanced stage, is still challenging; therefore, strategies to prevent metastatic dissemination are of great interest. Here the authors reveal a crucial role for liver X receptors in suppressing prostate carcinogenesis and metastatic progression in PTEN-null tumors.

    • Anthony Alioui
    • , Julie Dufour
    • , Valerio Leoni
    • , Anke Loregger
    • , Martina Moeton
    • , Luigi Iuliano
    • , Chiara Zerbinati
    • , Amandine Septier
    • , Pierre Val
    • , Allan Fouache
    • , Vincenzo Russo
    • , David H. Volle
    • , Jean-Marc A. Lobaccaro
    • , Noam Zelcer
    •  & Silvère Baron
  • Article | | open

    Stromal cells contribute to tumor development but the mechanisms regulating this process are still unclear. Here the authors analyze gene expression profiles in the prostate and show that stromal gene signature changes ahead of the epithelial gene signature as prostate cancer initiates and progresses.

    • Svitlana Tyekucheva
    • , Michaela Bowden
    • , Clyde Bango
    • , Francesca Giunchi
    • , Ying Huang
    • , Chensheng Zhou
    • , Arrigo Bondi
    • , Rosina Lis
    • , Mieke Van Hemelrijck
    • , Ove Andrén
    • , Sven-Olof Andersson
    • , R. William Watson
    • , Stephen Pennington
    • , Stephen P. Finn
    • , Neil E. Martin
    • , Meir J. Stampfer
    • , Giovanni Parmigiani
    • , Kathryn L. Penney
    • , Michelangelo Fiorentino
    • , Lorelei A. Mucci
    •  & Massimo Loda
  • Article | | open

    Tumours with homologous recombination (HR) defects become sensitive to PARPi. Here, the authors show that androgen receptor (AR) regulates HR and AR inhibition activates the PARP pathway in vivo, thus inhibition of both AR and PARP is required for effective treatment of high risk prostate cancer.

    • Mohammad Asim
    • , Firas Tarish
    • , Heather I. Zecchini
    • , Kumar Sanjiv
    • , Eleni Gelali
    • , Charles E. Massie
    • , Ajoeb Baridi
    • , Anne Y. Warren
    • , Wanfeng Zhao
    • , Christoph Ogris
    • , Leigh-Anne McDuffus
    • , Patrice Mascalchi
    • , Greg Shaw
    • , Harveer Dev
    • , Karan Wadhwa
    • , Paul Wijnhoven
    • , Josep V. Forment
    • , Scott R. Lyons
    • , Andy G. Lynch
    • , Cormac O’Neill
    • , Vincent R. Zecchini
    • , Paul S. Rennie
    • , Aria Baniahmad
    • , Simon Tavaré
    • , Ian G. Mills
    • , Yaron Galanty
    • , Nicola Crosetto
    • , Niklas Schultz
    • , David Neal
    •  & Thomas Helleday
  • Article | | open

    Urological cancers have disparate tissues and cells of origin but share many molecular features. Here, the authors use multidimensional and comprehensive molecular characterization to classify urological cancers into nine major genomic subtypes, highlighting potential therapeutic targets.

    • Fengju Chen
    • , Yiqun Zhang
    • , Dominick Bossé
    • , Aly-Khan A. Lalani
    • , A. Ari Hakimi
    • , James J. Hsieh
    • , Toni K. Choueiri
    • , Don L. Gibbons
    • , Michael Ittmann
    •  & Chad J. Creighton
  • Article | | open

    Invasion of malignant cells involves changes in cytoskeleton dynamics. Here the authors identify absent in melanoma 1 as an actin binding protein and show that it regulates cytoskeletal remodeling and cell migration in prostate epithelial cells, acting as a metastatic suppressor in cancer cells.

    • Michael C. Haffner
    • , David M. Esopi
    • , Alcides Chaux
    • , Meltem Gürel
    • , Susmita Ghosh
    • , Ajay M. Vaghasia
    • , Harrison Tsai
    • , Kunhwa Kim
    • , Nicole Castagna
    • , Hong Lam
    • , Jessica Hicks
    • , Nicolas Wyhs
    • , Debika Biswal Shinohara
    • , Paula J. Hurley
    • , Brian W. Simons
    • , Edward M. Schaeffer
    • , Tamara L. Lotan
    • , William B. Isaacs
    • , George J. Netto
    • , Angelo M. De Marzo
    • , William G. Nelson
    • , Steven S. An
    •  & Srinivasan Yegnasubramanian
  • Article | | open

    Prostate cancer is a heterogeneous disease, and many cases show somatic mutations of SPOP. Here, the authors show that a non-coding polymorphic regulatory element at 7p14.3 may predispose to SPOP mutant prostate cancer subclass through a hormone dependent DNA damage response.

    • Alessandro Romanel
    • , Sonia Garritano
    • , Blerta Stringa
    • , Mirjam Blattner
    • , Davide Dalfovo
    • , Dimple Chakravarty
    • , David Soong
    • , Kellie A. Cotter
    • , Gianluca Petris
    • , Priyanka Dhingra
    • , Paola Gasperini
    • , Anna Cereseto
    • , Olivier Elemento
    • , Andrea Sboner
    • , Ekta Khurana
    • , Alberto Inga
    • , Mark A. Rubin
    •  & Francesca Demichelis
  • Article | | open

    Folliculin is a known tumour suppressor but the molecular mechanisms behind this function are unclear. Here the authors show that Folliculin regulates EGFR signalling by modulating its Rab7a-dependent trafficking.

    • Laura A. Laviolette
    • , Julien Mermoud
    • , Isabel A. Calvo
    • , Nicholas Olson
    • , Myriam Boukhali
    • , Ortrud K. Steinlein
    • , Elisabeth Roider
    • , Elke C. Sattler
    • , Dachuan Huang
    • , Bin Tean Teh
    • , Mo Motamedi
    • , Wilhelm Haas
    •  & Othon Iliopoulos
  • Article | | open

    Renal cell carcinoma (RCC) is a common and aggressive malignancy. Here, the authors generate two mouse models of the most common RCC subtypes: the human papillary RCC through MYC activation and clear cell RCC through MYC activation combined with Vhl and Cdkn2a deletion.

    • Sean T. Bailey
    • , Aleisha M. Smith
    • , Jordan Kardos
    • , Sara E. Wobker
    • , Harper L. Wilson
    • , Bhavani Krishnan
    • , Ryoichi Saito
    • , Hyo Jin Lee
    • , Jing Zhang
    • , Samuel C. Eaton
    • , Lindsay A. Williams
    • , Ujjawal Manocha
    • , Dorien J. Peters
    • , Xinchao Pan
    • , Thomas J. Carroll
    • , Dean W. Felsher
    • , Vonn Walter
    • , Qing Zhang
    • , Joel S. Parker
    • , Jen Jen Yeh
    • , Richard A. Moffitt
    • , Janet Y. Leung
    •  & William Y. Kim
  • Article | | open

    Cell lines are central to cancer research, but knowing which cell lines are the best representative of actual tumours is a major challenge. Here the authors provide a resource assessment of 65 renal cell lines to assist researchers in selecting suitable lines for studying specific renal carcinoma subtypes.

    • Rileen Sinha
    • , Andrew G. Winer
    • , Michael Chevinsky
    • , Christopher Jakubowski
    • , Ying-Bei Chen
    • , Yiyu Dong
    • , Satish K. Tickoo
    • , Victor E. Reuter
    • , Paul Russo
    • , Jonathan A. Coleman
    • , Chris Sander
    • , James J. Hsieh
    •  & A. Ari Hakimi
  • Article | | open

    Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148.

    • Jun Fang
    • , Jinping Jia
    • , Matthew Makowski
    • , Mai Xu
    • , Zhaoming Wang
    • , Tongwu Zhang
    • , Jason W. Hoskins
    • , Jiyeon Choi
    • , Younghun Han
    • , Mingfeng Zhang
    • , Janelle Thomas
    • , Michael Kovacs
    • , Irene Collins
    • , Marta Dzyadyk
    • , Abbey Thompson
    • , Maura O'Neill
    • , Sudipto Das
    • , Qi Lan
    • , Roelof Koster
    • , PanScan Consortium
    • , Federico Canzian
    • , Charles Kooperberg
    • , Zhaoming Wang
    • , Alan A Arslan
    • , Paige M Bracci
    • , Julie Buring
    • , Eric J Duell
    • , Steven Gallinger
    • , Eric J Jacobs
    • , Aruna Kamineni
    • , Stephen Van Den Eeden
    • , Alison P Klein
    • , Laurence N Kolonel
    • , Donghui Li
    • , Sara H Olson
    • , Harvey A Risch
    • , Howard D Sesso
    • , Kala Visvanathan
    • , Wei Zheng
    • , Demetrius Albanes
    • , Melissa A Austin
    • , Marie-Christine Boutron-Ruault
    • , H Bas Bueno-de-Mesquita
    • , Michelle Cotterchio
    • , J Michael Gaziano
    • , Edward L Giovannucci
    • , Michael Goggins
    • , Myron Gross
    • , Manal Hassan
    • , Kathy J Helzlsouer
    • , Elizabeth A Holly
    • , David J Hunter
    • , Mazda Jenab
    • , Rudolf Kaaks
    • , Timothy J Key
    • , Kay-Tee Khaw
    • , Vittorio Krogh
    • , Robert C Kurtz
    • , Andrea LaCroix
    • , Loic Le Marchand
    • , Satu Mannisto
    • , Alpa V Patel
    • , Petra H M Peeters
    • , Elio Riboli
    • , Xiao-Ou Shu
    • , Malin Sund
    • , Mark Thornquist
    • , Anne Tjønneland
    • , Geoffrey S Tobias
    • , Dimitrios Trichopoulos
    • , Jean Wactawski-Wende
    • , Herbert Yu
    • , Kai Yu
    • , Anne Zeleniuch-Jacquotte
    • , Robert Hoover
    • , Patricia Hartge
    • , Charles Fuchs
    • , Stephen J Chanock
    • , TRICL Consortium
    • , Victoria Stevens
    • , Demetrios Albanes
    • , Neil E Caporaso
    • , Paul Brennan
    • , James McKay
    • , Xifeng Wu
    • , Rayjean J Hung
    • , John R McLaughlin
    • , Heike Bickeboller
    • , Angela Risch
    • , Erich Wichmann
    • , Richard Houlston
    • , GenoMEL Consortium
    • , Graham Mann
    • , John Hopper
    • , Joanne Aitken
    • , Bruce Armstrong
    • , Graham Giles
    • , Elizabeth Holland
    • , Richard Kefford
    • , Anne Cust
    • , Mark Jenkins
    • , Helen Schmid
    • , Susana Puig
    • , Paula Aguilera
    • , Celia Badenas
    • , Alicia Barreiro
    • , Cristina Carrera
    • , Daniel Gabriel
    • , Pol Gimenez-Xavier
    • , Pablo Iglesias-Garcia
    • , Josep Malvehy
    • , Montse Mila
    • , Ramon Pigem
    • , Miriam Potrony
    • , Joan Anton Puig-Batille
    • , Gemma Tell-Marti
    • , Nicholas K. Hayward
    • , Nicholas G. Martin
    • , Grant Montgomery
    • , David L. Duffy
    • , David C. Whiteman
    • , Stuart MacGregor
    • , Donato Calista
    • , Giorgi Landi
    • , Paola Minghetti
    • , Fabio Arcangeli
    • , Pier Alberto Bertazzi
    • , Paola Ghiorzo
    • , Giovanna Bianchi-Scarra
    • , Lorenze Pastorino
    • , William Bruno
    • , Virginia Andreotti
    • , Paola Queirolo
    • , Francesco Spagnolo
    • , Rona MacKie
    • , Julie Lang
    • , Nelleke Gruis
    • , Frans A van Nieuwpoort
    • , Coby Out
    • , Wilma Bergman
    • , Nicole Kukutsch
    • , Jan Nico Bouwes Bavinck
    • , Bert Bakker
    • , Nienke van der Stoep
    • , Jeanet ter Huurne
    • , Han van der Rhee
    • , Marcel Bekkenk
    • , Dyon Snels
    • , Marinus van Praag
    • , Lieve Brochez
    • , Rianne Gerritsen
    • , Marianne Crijns
    • , Hans Vasen
    • , Bart Janssen
    • , Christian Ingvar
    • , Håkan Olsson
    • , Göran Jönsson
    • , Åke Borg
    • , Katja Harbst
    • , Kari Nielsen
    • , Anita Schmidt Zander
    • , Anders Molvern
    • , Per Helsing
    • , Per Arne Andresen
    • , Helge Rootwelt
    • , Lars A Akslen
    • , Brigitte Bressac-de Paillerets
    • , Florence Demenais
    • , Marie-Francoise Avril
    • , Valerie Chaudru
    • , Patricia Jeannin
    • , Fabienne Lesueur
    • , Eve Maubec
    • , Hamida Mohamdi
    • , Myriam Bossard
    • , Amaury Vaysse
    • , Francoise Boitier
    • , Oliver Caron
    • , Frederic Caux
    • , Stephane Dalle
    • , Olivier Dereure
    • , Dominique Leroux
    • , Ludovic Martin
    • , Christine Mateus
    • , Caroline Robert
    • , Dominique Stoppa-Lyonnet
    • , Luc Thomas
    • , Eva Wierzbicka
    • , David E. Elder
    • , Michael Ming
    • , Nandita Mitra
    • , Tadeusz Debniak
    • , Jan Lubinski
    • , Marko Hocevar
    • , Srdjan Novakovic
    • , Barbara Peric
    • , Petra Skerl
    • , Johan Hansson
    • , Veronica Höiom
    • , Eitan Freidman
    • , Esther Azizi
    • , Orna Baron-Epel
    • , Alon Scope
    • , Felix Pavlotsky
    • , Irit Cohen-Manheim
    • , Yael Laitman
    • , Mark Harland
    • , Juliette Randerson-Moor
    • , Jon Laye
    • , John Davies
    • , Jeremie Nsengimana
    • , Sally O'Shea
    • , May Chan
    • , Jo Gascoyne
    • , Margaret A Tucker
    • , Alisa M Goldstein
    • , Xiaohong R Yang
    • , Rachael S. Stolzenberg-Solomon
    • , Peter Kraft
    • , Brian M. Wolpin
    • , Pascal W. T. C. Jansen
    • , Sara Olson
    • , Katherine A. McGlynn
    • , Peter A. Kanetsky
    • , Nilanjan Chatterjee
    • , Jennifer H. Barrett
    • , Alison M. Dunning
    • , John C. Taylor
    • , Julia A. Newton-Bishop
    • , D. Timothy Bishop
    • , Thorkell Andresson
    • , Gloria M. Petersen
    • , Christopher I. Amos
    • , Mark M. Iles
    • , Katherine L. Nathanson
    • , Maria Teresa Landi
    • , Michiel Vermeulen
    • , Kevin M. Brown
    •  & Laufey T. Amundadottir
  • Article | | open

    Dysregulation of microRNAs is thought to be important for metastasis in castration-resistant prostate cancer (CRPC), but its drivers are unknown. Here, the authors use computational analysis to identify HOXC6 and NKX2-2 in addition to AR as alternative drivers of dysregulated miRNA expression in CRPC.

    • Mengzhu Xue
    • , Haiyue Liu
    • , Liwen Zhang
    • , Hongyuan Chang
    • , Yuwei Liu
    • , Shaowei Du
    • , Yingqun Yang
    •  & Peng Wang
  • Article | | open

    Prostate-specific antigen is used as a biomarker of prostate cancer, but levels can be affected by other factors not related to cancer. Here, the authors find genes associated with prostate specific antigen levels in healthy men, which could be used to reduce over-diagnosis and over-treatment.

    • Thomas J. Hoffmann
    • , Michael N. Passarelli
    • , Rebecca E. Graff
    • , Nima C. Emami
    • , Lori C. Sakoda
    • , Eric Jorgenson
    • , Laurel A. Habel
    • , Jun Shan
    • , Dilrini K. Ranatunga
    • , Charles P. Quesenberry
    • , Chun R. Chao
    • , Nirupa R. Ghai
    • , David Aaronson
    • , Joseph Presti
    • , Tobias Nordström
    • , Zhaoming Wang
    • , Sonja I. Berndt
    • , Stephen J. Chanock
    • , Jonathan D. Mosley
    • , Robert J. Klein
    • , Mridu Middha
    • , Hans Lilja
    • , Olle Melander
    • , Mark N. Kvale
    • , Pui-Yan Kwok
    • , Catherine Schaefer
    • , Neil Risch
    • , Stephen K. Van Den Eeden
    •  & John S. Witte
  • Article | | open

    MicroRNAs have important roles in regulating tumor development, progression and metastasis. Here, the authors demonstrate the tumor-suppressive functions of miRNA141 in prostate cancer stem cells mediated by directly targeting CD44, Rho GTPase protein family members, and EZH2.

    • Can Liu
    • , Ruifang Liu
    • , Dingxiao Zhang
    • , Qu Deng
    • , Bigang Liu
    • , Hsueh-Ping Chao
    • , Kiera Rycaj
    • , Yoko Takata
    • , Kevin Lin
    • , Yue Lu
    • , Yi Zhong
    • , John Krolewski
    • , Jianjun Shen
    •  & Dean G. Tang
  • Article | | open

    Men that carrier BRCA2 germline mutations are at risk of developing prostate cancer. Here, the authors analyse the genomes of prostate cancer from these individuals and demonstrate increased genomic instability in comparison to sporadic prostate cancer.

    • Renea A. Taylor
    • , Michael Fraser
    • , Julie Livingstone
    • , Shadrielle Melijah G. Espiritu
    • , Heather Thorne
    • , Vincent Huang
    • , Winnie Lo
    • , Yu-Jia Shiah
    • , Takafumi N. Yamaguchi
    • , Ania Sliwinski
    • , Sheri Horsburgh
    • , Alice Meng
    • , Lawrence E. Heisler
    • , Nancy Yu
    • , Fouad Yousif
    • , Melissa Papargiris
    • , Mitchell G. Lawrence
    • , Lee Timms
    • , Declan G. Murphy
    • , Mark Frydenberg
    • , Julia F. Hopkins
    • , Damien Bolton
    • , David Clouston
    • , John D. McPherson
    • , Theodorus van der Kwast
    • , Paul C. Boutros
    • , Gail P. Risbridger
    •  & Robert G. Bristow
  • Article | | open

    There is some evidence of a hereditary risk for developing testicular germ cell tumours. Here, the authors use whole-exome sequencing and identify a risk variant for the disease in DNAAF1, a gene involved in microtubule-based cilia.

    • Kevin Litchfield
    • , Max Levy
    • , Darshna Dudakia
    • , Paula Proszek
    • , Claire Shipley
    • , Sander Basten
    • , Elizabeth Rapley
    • , D. Timothy Bishop
    • , Alison Reid
    • , Robert Huddart
    • , Peter Broderick
    • , David Gonzalez de Castro
    • , Simon O'Connor
    • , Rachel H. Giles
    • , Richard S. Houlston
    •  & Clare Turnbull
  • Article | | open

    Prostate cancers often become castration resistant due to alternative expression of androgen receptor (AR) splice variants. Here, the authors screened a library of natural compounds and identified Ailanthone as a potent inhibitor of AR through its binding to the co-chaperone protein p23 that, by preventing AR interaction with HSP90, results in ubiquitin/proteasome-mediated degradation of the receptor.

    • Yundong He
    • , Shihong Peng
    • , Jinhua Wang
    • , Huang Chen
    • , Xiaonan Cong
    • , Ang Chen
    • , Meichun Hu
    • , Min Qin
    • , Haigang Wu
    • , Shuman Gao
    • , Liguo Wang
    • , Xin Wang
    • , Zhengfang Yi
    •  & Mingyao Liu
  • Article | | open

    Notch signalling is involved in prostate cancer progression and therapeutic resistance. Here, the authors show that loss of PTEN in prostate cancer models results in increased Notch1 cleavage and activation through CUX1-mediated transactivation of ADAM17.

    • Ajinkya Revandkar
    • , Maria Luna Perciato
    • , Alberto Toso
    • , Abdullah Alajati
    • , Jingjing Chen
    • , Hermeto Gerber
    • , Mitko Dimitrov
    • , Andrea Rinaldi
    • , Nicolas Delaleu
    • , Emiliano Pasquini
    • , Rocco D’Antuono
    • , Sandra Pinton
    • , Marco Losa
    • , Letizia Gnetti
    • , Alberto Arribas
    • , Patrick Fraering
    • , Francesco Bertoni
    • , Alain Nepveu
    •  & Andrea Alimonti
  • Article | | open

    Castration-resistant prostate cancer frequently presents with persistent androgen receptor signalling. Here, the authors find that the androgen receptor is subject to genetic rearrangements, resulting in variants with ligand-independent activity.

    • Christine Henzler
    • , Yingming Li
    • , Rendong Yang
    • , Terri McBride
    • , Yeung Ho
    • , Cynthia Sprenger
    • , Gang Liu
    • , Ilsa Coleman
    • , Bryce Lakely
    • , Rui Li
    • , Shihong Ma
    • , Sean R. Landman
    • , Vipin Kumar
    • , Tae Hyun Hwang
    • , Ganesh V. Raj
    • , Celestia S. Higano
    • , Colm Morrissey
    • , Peter S. Nelson
    • , Stephen R. Plymate
    •  & Scott M. Dehm
  • Article | | open

    Renal tumour-initiating cells (T-ICs) contribute to tumour initiation and progression. Here, the authors show that lncARSR regulates TICs by blocking LATS1-induced YAP phosphorylation facilitating YAP nuclear translocation, which promotes lncARSR transcription, thus forming a feed-forward circuit to promote TIC expansion.

    • Le Qu
    • , Zhenjie Wu
    • , Yaoming Li
    • , Zhipeng Xu
    • , Bing Liu
    • , Feng Liu
    • , Yi Bao
    • , Dengshuang Wu
    • , Jiayi Liu
    • , Anbang Wang
    • , Xiaoyuan Chu
    • , Yinghao Sun
    • , Cheng Chen
    • , Zhengyu Zhang
    •  & Linhui Wang