Ubiquitylation articles from across Nature Portfolio

Here the authors show that the basal activation of the interferon/ISG15 pathway is required for the stability of nascent DNA during replication and its upregulation promotes viability, proliferation and acquisition of drug resistance in BRCA1/2 deficient cells.

The crosstalk between innate immunity and autophagy plays a critical role in cancer. Here, the authors report that an immune receptor NLRP6 potentiates the PI3K/AKT pathway by selective degradation of p85α. The NLRP6-p85α interaction offers a potential therapeutic target for tumor treatment.

Scott et al. describe a mechanism based on C-degron mimicry by which an E3 ubiquitin ligase discriminates bona fide substrates from non-physiological substrates.

Myocardial ischemia–reperfusion injury is more severe during the sleep-to-wake transition period of the day. A new study shows that timed administration of digoxin, a cardiac glycoside approved by the US Food and Drug Administration, prevents experimental myocardial ischemia–reperfusion injury by controlling proteostasis of the circadian-clock regulator Rev-Erbα.