Tumour heterogeneity

Tumour heterogeneity describes differences between tumours of the same type in different patients, and between cancer cells within a tumour. Both can lead to different responses to therapy. Genetic and epigenetic differences between cancer cells within a tumour might explain why some tumour cells remain present in the patient after cancer treatment has finished.

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News and Comment

  • News & Views |

    Therapeutic resistance in prostate cancer can be driven by lineage plasticity, but the mechanisms behind this are unclear, and therapies to prevent or reverse the process are nonexistent. A new study reveals the JAK/STAT signaling axis as a driver of lineage plasticity with tremendous therapeutic potential.

    • Nicholas J. Brady
    •  & Christopher E. Barbieri
    Nature Cancer 3, 1021-1023
  • News & Views |

    By quantifying thousands of proteins in tumor cells in an unbiased manner, Deep Visual Proteomics uncovers mechanisms that drive tumor evolution and reveals new therapeutic targets. The method incorporates advanced microscopy, artificial intelligence and ultra-high-sensitivity proteomics to characterize individual cell identities.

    Nature Biotechnology 40, 1186-1187
  • Research Highlights |

    In this Tools of the Trade article, Yaara Oren describes the development and use of the Watermelon system to simultaneously track the lineage, transcriptional profile and proliferative state of each cancer cell in a population, which enables the characterization of rare cycling persister cells.

    • Yaara Oren
    Nature Reviews Cancer 22, 434-435
  • News & Views |

    Prognostic models incorporating clinical and pathological parameters might assist clinicians in counselling and surveillance of patients following surgical resection of renal cell carcinoma (RCC). Variability exists in the risk classification of individual patients in each model as well as the performance of each model in different RCC subtypes.

    • Thomas Gerald
    •  & Vitaly Margulis