Tuberculosis

Tuberculosis (TB) is an infectious disease caused by strains of bacteria known as mycobacteria. The disease most commonly affects the lungs and can be fatal if not treated. However, most infected individuals show no disease symptoms. One third of the world’s population is thought to have been infected with TB.

Latest Research and Reviews

  • Research
    | Open Access

    Previous work has suggested potential links between Mycobacterium tuberculosis infection and the development of both lung cancer and sarcoidosis, in addition to tuberculosis. Here, Qiyao Chai, Zhe Lu, Zhidong Liu and colleagues report a transcriptomic analysis of lung tissue from tuberculosis, lung adenocarcinoma, and sarcoidosis patients and find that while many disease-linked expression changes are shared between the three diseases, each also has distinct transcriptional signatures that could be useful as molecular markers.

    • Qiyao Chai
    • , Zhe Lu
    • , Zhidong Liu
    • , Yanzhao Zhong
    • , Fuzhen Zhang
    • , Changgen Qiu
    • , Bingxi Li
    • , Jing Wang
    • , Lingqiang Zhang
    • , Yu Pang
    •  & Cui Hua Liu
  • Research
    | Open Access

    Metformin is an anti-diabetic drug that has shown promise to reduce M. tuberculosis susceptibility. Here the authors show that this effect is a result of metformin-mediated activation of anti-mycobacterial memory-like antigen-inexperienced CD8+CXCR3+ T cells, an effect that also boosts response to BCG vaccination.

    • Julia Böhme
    • , Nuria Martinez
    • , Shamin Li
    • , Andrea Lee
    • , Mardiana Marzuki
    • , Anteneh Mehari Tizazu
    • , David Ackart
    • , Jessica Haugen Frenkel
    • , Alexandra Todd
    • , Ekta Lachmandas
    • , Josephine Lum
    • , Foo Shihui
    • , Tze Pin Ng
    • , Bernett Lee
    • , Anis Larbi
    • , Mihai G. Netea
    • , Randall Basaraba
    • , Reinout van Crevel
    • , Evan Newell
    • , Hardy Kornfeld
    •  & Amit Singhal
  • Research
    | Open Access

    Virginie Rozot and Elisa Nemes et al. report comprehensive profiling of immune responses from participants in a recent clinical trial of the H4:IC31 and BCG vaccines against Mycobacterium tuberculosis infection. Using a novel analysis platform, they uncover complex vaccine-induced modulation of different immune cell subsets.

    • Virginie Rozot
    • , Elisa Nemes
    • , Hennie Geldenhuys
    • , Munyaradzi Musvosvi
    • , Asma Toefy
    • , Frances Rantangee
    • , Lebohang Makhethe
    • , Mzwandile Erasmus
    • , Nicole Bilek
    • , Simbarashe Mabwe
    • , Greg Finak
    • , William Fulp
    • , Ann M. Ginsberg
    • , David A. Hokey
    • , Muki Shey
    • , Sanjay Gurunathan
    • , Carlos DiazGranados
    • , Linda-Gail Bekker
    • , Mark Hatherill
    • , Thomas J. Scriba
    • , Charmaine Abrahams
    • , Marcelene Aderiye
    • , Hadn Africa
    • , Deidre Albertyn
    • , Fadia Alexander
    • , Julia Amsterdam
    • , Peter Andersen
    • , Denis Arendsen
    • , Hanlie Bester
    • , Elizabeth Beyers
    • , Natasja Botes
    • , Janelle Botes
    • , Samentra Braaf
    • , Roger Brooks
    • , Yolundi Cloete
    • , Alessandro Companie
    • , Kristin Croucher
    • , Ilse Davids
    • , Guy de Bruyn
    • , Bongani Diamond
    • , Portia Dlakavu
    • , Palesa Dolo
    • , Sahlah Dubel
    • , Cindy Elbring
    • , Ruth D. Ellis
    • , Margareth Erasmus
    • , Terence Esterhuizen
    • , Thomas Evans
    • , Christine Fattore
    • , Sebastian Gelderbloem
    • , Diann Gempies
    • , Sandra Goliath
    • , Peggy Gomes
    • , Yolande Gregg
    • , Elizabeth Hamilton
    • , Willem A. Hanekom
    • , Johanna Hector
    • , Roxanne Herling
    • , Yulandi Herselman
    • , Robert Hopkins
    • , Jane Hughes
    • , Devin Hunt
    • , Henry Issel
    • , Helene Janosczyk
    • , Lungisa Jaxa
    • , Carolyn Jones
    • , Jateel Kassiem
    • , Sophie Keffers
    • , Xoliswa Kelepu
    • , Alana Keyser
    • , Alexia Kieffer
    • , Ingrid Kromann
    • , Sandra Kruger
    • , Maureen Lambrick
    • , Bernard Landry
    • , Phumzile Langata
    • , Maria Lempicki
    • , Marie-Christine Locas
    • , Angelique Luabeya
    • , Lauren Mactavie
    • , Lydia Makunzi
    • , Pamela Mangala
    • , Clive Maqubela
    • , Boitumelo Mosito
    • , Angelique Mouton
    • , Humphrey Mulenga
    • , Mariana Mullins
    • , Julia Noble
    • , Onke Nombida
    • , Dawn O’Dee
    • , Amy O’Neil
    • , Rose Ockhuis
    • , Saleha Omarjee
    • , Fajwa Opperman
    • , Dhaval Patel
    • , Christel Petersen
    • , Abraham Pretorius
    • , Debbie Pretorius
    • , Michael Raine
    • , Rodney Raphela
    • , Maigan Ratangee
    • , Christian Rauner
    • , Susan Rossouw
    • , Surita Roux
    • , Kathryn Tucker Rutkowski
    • , Robert Ryall
    • , Elisma Schoeman
    • , Constance Schreuder
    • , Steven G. Self
    • , Cashwin September
    • , Justin Shenje
    • , Barbara Shepherd
    • , Heather Siefers
    • , Eunice Sinandile
    • , Danna Skea
    • , Marcia Steyn
    • , Jin Su
    • , Sharon Sutton
    • , Anne Swarts
    • , Patrick Syntin
    • , Michele Tameris
    • , Petrus Tyambetyu
    • , Arrie van der Merwe
    • , Elize van der Riet
    • , Dorothy van der Vendt
    • , Denise van der Westhuizen
    • , Anja van der Westhuizen
    • , Elma van Rooyen
    • , Ashley Veldsman
    • , Helen Veltdsman
    • , Emerencia Vermeulen
    • , Sindile Wiseman Matiwane
    •  & Noncedo Xoyana

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