tRNAs

Transfer RNAs (tRNAs) are a type of non-coding ribonucleic acid (ncRNA) that carry specific amino acids and recognize unique messenger RNA (mRNA) sequences. The pairing of a tRNA to its compatible mRNA sequence within the ribosome is the basis for the translation of RNA into protein.

Latest Research and Reviews

  • Research
    | Open Access

    E. coli and human tRNAs contain 3-(3-amino-3-carboxypropyl)uridine (acp3U) modification. Here the authors identify E. coli TapT and human DTWD1/2 as tRNA aminocarboxypropyltransferases responsible for acp3U formation. Inhibition of acp3U modification results in genome instability in heat-stressed E. coli and growth defects in human cells.

    • Mayuko Takakura
    • , Kensuke Ishiguro
    • , Shinichiro Akichika
    • , Kenjyo Miyauchi
    •  & Tsutomu Suzuki
  • Research |

    Single-molecule dynamics reveal that the GTPase activity of eukaryotic initiation factor eIF5B serves as a kinetic checkpoint for the transition from translation initiation to elongation.

    • Jinfan Wang
    • , Alex G. Johnson
    • , Christopher P. Lapointe
    • , Junhong Choi
    • , Arjun Prabhakar
    • , Dong-Hua Chen
    • , Alexey N. Petrov
    •  & Joseph D. Puglisi
    Nature 573, 605-608
  • Research
    | Open Access

    The biosynthesis of N6-threonylcarbamoylated adenosine 37 in tRNA (t6A) involves the YRDC enzyme and the KEOPS complex. Here, the authors report mutations in YRDC and the KEOPS component GON7 in Galloway-Mowat syndrome and determine the crystal structure of a GON7-containg subcomplex that suggests a role in KEOPS complex stability.

    • Christelle Arrondel
    • , Sophia Missoury
    • , Rozemarijn Snoek
    • , Julie Patat
    • , Giulia Menara
    • , Bruno Collinet
    • , Dominique Liger
    • , Dominique Durand
    • , Olivier Gribouval
    • , Olivia Boyer
    • , Laurine Buscara
    • , Gaëlle Martin
    • , Eduardo Machuca
    • , Fabien Nevo
    • , Ewen Lescop
    • , Daniela A. Braun
    • , Anne-Claire Boschat
    • , Sylvia Sanquer
    • , Ida Chiara Guerrera
    • , Patrick Revy
    • , Mélanie Parisot
    • , Cécile Masson
    • , Nathalie Boddaert
    • , Marina Charbit
    • , Stéphane Decramer
    • , Robert Novo
    • , Marie-Alice Macher
    • , Bruno Ranchin
    • , Justine Bacchetta
    • , Audrey Laurent
    • , Sophie Collardeau-Frachon
    • , Albertien M. van Eerde
    • , Friedhelm Hildebrandt
    • , Daniella Magen
    • , Corinne Antignac
    • , Herman van Tilbeurgh
    •  & Géraldine Mollet
  • Research
    | Open Access

    MazF endoribonucleases are thought to arrest growth of Mycobacterium tuberculosis by global translation inhibition. Here, Barth et al. show that MazF-mt9 cleaves a specific tRNA, leading to ribosome stalling at AAA codons and thus selective mRNA degradation and changes in transcriptome and proteome.

    • Valdir C. Barth
    • , Ju-Mei Zeng
    • , Irina O. Vvedenskaya
    • , Ming Ouyang
    • , Robert N. Husson
    •  & Nancy A. Woychik
  • Research
    | Open Access

    Adenovirus Virus-Associated (VA) noncoding RNAs interfere with the host system by mimicking double stranded RNAs. Here, the authors report a 2.7 Å crystal structure of VA-I RNA providing an understanding of its function.

    • Iris V. Hood
    • , Jackson M. Gordon
    • , Charles Bou-Nader
    • , Frances E. Henderson
    • , Soheila Bahmanjah
    •  & Jinwei Zhang

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