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Transporters in the nervous system are proteins that span the plasma membrane and are involved in movement of ions and molecules across the membrane. They include neurotransmitter transporters, which move neurotransmitters or their metabolites from the extracellular space into a neuron, and vesicular transporters, which are involved in filling synaptic vesicles.
VMAT2 regulates neurotransmitter uptake into synaptic vesicles. Here, the authors determined the cryo-EM structures of VMAT2, providing a structural basis for understanding VMAT2- mediated vesicular transport of neurotransmitters.
Structures of human NET in the apo state and bound to meta-iodobenzylguanidine and radafaxine provide insights into the mechanism of substrate recognition and orthosteric inhibition of hNET.
Cryo-electron microscopy structure of the human dopamine transporter in complex with multiple inhibitors illuminates mechanisms of allosteric inhibition.
A study using cryo-electron microscopy has determined the structure of the human dopamine transporter with bound cocaine, revealing molecular details about neurotransmitter transport and how it is affected by neuropsychiatric drugs.
The VGLUT3-p.T8I mutation was identified in patients with SUDs and EDs and introduced in a mouse line. Here, authors show that mutant mice have an imbalanced DA signaling in the dorsal striatum associated with maladaptive cocaine and food consumption.
The presence of sugar in the gut is signalled via the vagus nerve to neurons in the caudal nucleus of the solitary tract, which help to mediate the formation of the preference for sugar over sweeteners.
Restoring function of the K+/Cl– co-transporter KCC2 in spinal inhibitory interneurons spared after spinal cord injury helps the recovery of hindlimb function in mice.
