Translational research articles from across Nature Portfolio

Translational research involves the application of knowledge gained through basic research to studies that could support the development of new products. For example, translational research in the field of medicine may involve using knowledge of the biology of a disease to identify and evaluate chemical compounds in disease models, with a view to selecting potential candidate drugs to advance into clinical trials.

Featured

News & Views | 17 May 2023

Selection by essential-gene exon knock-in for the generation of efficient cell therapies

Nature Biotechnology, 1-2

Latest Research and Reviews

Research
02 June 2023 | Open Access

Murine studies and expressional analyses of human cardiac pericytes reveal novel trajectories of SARS-CoV-2 Spike protein-induced microvascular damage
- Elisa Avolio
- , Prashant K. Srivastava
- & Paolo Madeddu
Signal Transduction and Targeted Therapy 8, 232
Research | 01 June 2023

Genomic profiling informs diagnoses and treatment in vascular anomalies

Genomic and cell-free DNA sequencing clarify the clinical diagnosis and inform treatment initiation in a cohort of 356 patients with vascular anomalies.
- Dong Li
- , Sarah E. Sheppard
- & Hakon Hakonarson
Nature Medicine, 1-10
Research
01 June 2023 | Open Access

Identification of genetic loci associated with renal dysfunction after lung transplantation using an ethnic-specific single-nucleotide polymorphism array
- Yasuaki Tomioka
- , Seiichiro Sugimoto
- & Shinichi Toyooka
Scientific Reports 13, 8912
Reviews
31 May 2023 | Open Access

Rigorous and rapid evidence assessment in digital health with the evidence DEFINED framework
- Jordan Silberman
- , Paul Wicks
- & Jennifer C. Goldsack
npj Digital Medicine 6, 101
Research
31 May 2023 | Open Access

Host-diet-gut microbiome interactions influence human energy balance: a randomized clinical trial

The gut microbiome is causally linked to body weight in preclinical models. Here, in a controlled feeding study, the authors show that greater delivery of gut-microbiome fermentable dietary substrates to the colon leads to a net negative energy balance that is accompanied by robust microbial and host responses.
- Karen D. Corbin
- , Elvis A. Carnero
- & Steven R. Smith
Nature Communications 14, 3161
Research
31 May 2023 | Open Access

An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment

Osteoarthritis is a common disease that causes pain and difficulty moving joints. Here the authors present an injectable gelatin-based hydrogel that slowly releases teriparatide drug to avoid frequent injections, offering a potential solution for patients with osteoarthritis.
- Guoqing Li
- , Su Liu
- & Hui Zeng
Nature Communications 14, 3159

All Research & Reviews

News and Comment

Editorial
31 May 2023 | Open Access

Understanding the scalability of personalised monitoring within indoor spaces

Health and wellness/well-being are multifaceted topics further complicated when trying to understand the environmental impact. Typically, there has been a one size fits all approach when trying to understand the 3-way interaction, but that is a limited approach. Equally, measurement (of each) has often used a limited set of outcomes during short periods to provide insight. A more robust understanding of health and well-being within environments may require longitudinal/continuous assessment that holistically targets individuals. Therefore, there is a growing requirement for careful data management, individual-first methodologies, scalable research designs and new analytical approaches, e.g., artificial intelligence. That presents many challenges but interesting research opportunities for the field of digital medicine.
- Graham Coulby
- & Alan Godfrey
npj Digital Medicine 6, 102
Editorial
31 May 2023 | Open Access

The digital transformation of surgery
- Jayson S. Marwaha
- , Marium M. Raza
- & Joseph C. Kvedar
npj Digital Medicine 6, 103
Comments & Opinion | 29 May 2023

Lessons learned from translating AI from development to deployment in healthcare

The application of an artificial intelligence (AI)-based screening tool for retinal disease in India and Thailand highlighted the myths and reality of introducing medical AI, which may form a framework for subsequent tools
- Kasumi Widner
- , Sunny Virmani
- & Dale R. Webster
Nature Medicine, 1-3
News & Views | 17 May 2023

Selection by essential-gene exon knock-in for the generation of efficient cell therapies

By linking transgene expression with that of a housekeeping gene, SLEEK (selection by essential-gene exon knock-in) enables efficient knock-in of complex cargos in a variety of clinically relevant cell types. Using SLEEK, we were able to substantially improve the tumor suppression ability and in vivo persistence of a cell therapy.

Nature Biotechnology, 1-2
Comments & Opinion | 12 May 2023

Soft devices in neurological surgery

The translation of soft biomedical devices from academia to commercialization remains limited despite the substantial growth of the field over the past decade. To drive the next stage of innovation, it is crucial to identify applications that can be uniquely addressed by soft devices. Neurological surgery presents numerous opportunities for harnessing the potential of soft devices in medical applications.
- Sabrina Smith
- , Rosalie Ogborne
- & Firat Güder
Nature Reviews Materials, 1-3
Research Highlights | 12 May 2023

Targeting senescent cells in ageing-related endocrine diseases
- Joshua Stokar
Nature Reviews Endocrinology 19, 382

All News & Comment

Translational research articles from across Nature Portfolio

Featured

Selection by essential-gene exon knock-in for the generation of efficient cell therapies

Latest Research and Reviews

Murine studies and expressional analyses of human cardiac pericytes reveal novel trajectories of SARS-CoV-2 Spike protein-induced microvascular damage

Genomic profiling informs diagnoses and treatment in vascular anomalies

Identification of genetic loci associated with renal dysfunction after lung transplantation using an ethnic-specific single-nucleotide polymorphism array

Rigorous and rapid evidence assessment in digital health with the evidence DEFINED framework

Host-diet-gut microbiome interactions influence human energy balance: a randomized clinical trial

An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment

News and Comment

Understanding the scalability of personalised monitoring within indoor spaces

The digital transformation of surgery

Lessons learned from translating AI from development to deployment in healthcare

Selection by essential-gene exon knock-in for the generation of efficient cell therapies

Soft devices in neurological surgery

Targeting senescent cells in ageing-related endocrine diseases

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