Translational research articles from across Nature Portfolio

We developed ehrapy, an open-source Python software framework for the exploratory analysis of electronic health record data. Ehrapy handles various widely used data formats, preprocessing tasks such as imputation of missing data and bias detection, and offers tools for analyses including patient stratification, survival analysis, causal inference and trajectory inference.

Staphylococcus aureus infection results in robust induction of immunity but the development of efficacious vaccines remains challenging. Here the authors present a vaccine that amplifies T cell immunity early in life by targeting the S. aureus α-toxin-ADAM10 interaction in a murine model.

We developed ehrapy, an open-source Python software framework for the exploratory analysis of electronic health record data. Ehrapy handles various widely used data formats, preprocessing tasks such as imputation of missing data and bias detection, and offers tools for analyses including patient stratification, survival analysis, causal inference and trajectory inference.

Post-approval evidence generation is essential for high-quality clinical care and should be a shared priority for clinicians, health systems, payors, and the medical products industry, as well as the FDA and federal agencies.