Translation

Definition

Translation is the process by which a protein is synthesized by the ribosome, using a messenger RNA (mRNA) template.

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Latest Research and Reviews

  • Research |

    A high-resolution structure of the human ribosome determined by cryo-electron microscopy visualizes numerous RNA modifications that are concentrated at functional sites with an extended shell, and suggests the possibility of designing more specific ribosome-targeting drugs.

    • S. Kundhavai Natchiar
    • , Alexander G. Myasnikov
    • , Hanna Kratzat
    • , Isabelle Hazemann
    •  & Bruno P. Klaholz
  • Research | | open

    Leishmaniasis is a parasitic disease transmitted by the bite of infected sand flies. Here the authors describe an atomic resolution cryo-EM structure of the Leishmania ribosome in complex with the recently approved drug paromomycin (PAR) and highlight conserved elements in the drug binding pocket that mediate PAR deleterious effects on the parasite.

    • Moran Shalev-Benami
    • , Yan Zhang
    • , Haim Rozenberg
    • , Yuko Nobe
    • , Masato Taoka
    • , Donna Matzov
    • , Ella Zimmerman
    • , Anat Bashan
    • , Toshiaki Isobe
    • , Charles L. Jaffe
    • , Ada Yonath
    •  & Georgios Skiniotis
  • Research | | open

    The RNA-binding protein CsrA regulates the expression of hundreds of bacterial genes. Here, Potts et al. use several approaches to assess the contribution of CsrA to global gene expression in E. coli, revealing new binding targets and physiological roles such as in envelope function and iron homeostasis.

    • Anastasia H. Potts
    • , Christopher A. Vakulskas
    • , Archana Pannuri
    • , Helen Yakhnin
    • , Paul Babitzke
    •  & Tony Romeo
  • Research | | open

    Fbxo4 tumour suppressor is part of a SCF E3 ligase which has two known substrates. Here, the authors identify Fxr1 as a substrate of SCFFbxo4 and identify an inherent regulatory feedback loop in head and neck squamous cell carcinoma that results in the bypass of senescence and neoplastic progression.

    • Shuo Qie
    • , Mrinmoyee Majumder
    • , Katarzyna Mackiewicz
    • , Breege V. Howley
    • , Yuri K. Peterson
    • , Philip H. Howe
    • , Viswanathan Palanisamy
    •  & J. Alan Diehl
  • Research | | open

    tRNA-dependent cysteine biosynthesis is catalyzed by the transsulfursome protein complex. Here, the authors use a multidisciplinary approach to structurally characterize the archaeal transsulfursome and propose a model for tRNA channeling in the complex.

    • Meirong Chen
    • , Koji Kato
    • , Yume Kubo
    • , Yoshikazu Tanaka
    • , Yuchen Liu
    • , Feng Long
    • , William B. Whitman
    • , Pascal Lill
    • , Christos Gatsogiannis
    • , Stefan Raunser
    • , Nobutaka Shimizu
    • , Akira Shinoda
    • , Akiyoshi Nakamura
    • , Isao Tanaka
    •  & Min Yao

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