Transcriptomics

Transcriptomics is the study of the transcriptome—the complete set of RNA transcripts that are produced by the genome, under specific circumstances or in a specific cell—using high-throughput methods, such as microarray analysis. Comparison of transcriptomes allows the identification of genes that are differentially expressed in distinct cell populations, or in response to different treatments.

Featured

Latest Research and Reviews

News and Comment

  • News and Views |

    Cellular senescence has been widely recognised for decades as a stable arrest of cell proliferation. A recent study identifies senescence establishment and maintenance as a dynamic and reversible process regulated by (in)activation of a predetermined enhancer landscape controlled by the pioneer transcription factor AP-1.

    • Sara Zumerle
    •  & Andrea Alimonti
    Nature Cell Biology 22, 753-754
  • Research Highlights |

    A new study in Cell describes the CRISPR array repair lineage tracing (CARLIN) engineered mouse line that genomically encodes all the components for CRISPR-based lineage tracking at single-cell resolution.

    • Darren J. Burgess
  • Research Highlights |

    Two papers in Nature Chemical Biology describe new methods for transcriptome-mapping of N6-methyladenosine (m6A), a covalent modification of RNA. In m6A-SEAL, modified adenosines can be tagged with different functional groups for different applications, whereas m6A-label-seq uses metabolic labelling to achieve single-nucleotide resolution.

    • Dorothy Clyde
  • Research Highlights |

    Snake venom gland organoids provide a glimpse into the cell biology of the respective organ and serve as a platform for producing snake toxins.

    • Nina Vogt
    Nature Methods 17, 360