Transcription

Transcription is the process by which an RNA polymerase synthesizes ribonucleic acid (RNA) using deoxyribonucleic acid (DNA) as a template.

Latest Research and Reviews

  • Research | | open

    Chromatin looping allows for enhancer–promoter interactions that regulate transcription. Here the authors show that activation of embryonic myogenesis is associated with establishment of long-range chromatin interactions centred on Pax3-bound loci and find that Ldb1 functions as the mediator of looping interactions at a subset of Pax3 binding sites.

    • Alessandro Magli
    • , June Baik
    • , Pruthvi Pota
    • , Carolina Ortiz Cordero
    • , Il-Youp Kwak
    • , Daniel J. Garry
    • , Paul E. Love
    • , Brian D. Dynlacht
    •  & Rita C. R. Perlingeiro
  • Reviews |

    Gene expression is subjected to various random processes (referred to as ‘noise’) that contribute to variability in molecular phenotypes. As Eling, Morgan and Marioni describe, there are various challenges to studying this variability, such as disentangling its multilayered sources, distinguishing it from deterministic influences on cellular variability, modelling it with appropriate statistical methods and understanding its practical consequences.

    • Nils Eling
    • , Michael D. Morgan
    •  & John C. Marioni
  • Research | | open

    Idiopathic pulmonary fibrosis (IPF) is a lethal disease with insufficient treatment strategies. Here the authors show that reduction of the microRNA MIRLET7D and hyperactivation of EP300 contribute to impaired epigenetic silencing by the MiCEE complex in pulmonary fibroblasts of IPF patients, and demonstrate the benefit of inhibiting EP300 for the treatment of IPF.

    • Karla Rubio
    • , Indrabahadur Singh
    • , Stephanie Dobersch
    • , Pouya Sarvari
    • , Stefan Günther
    • , Julio Cordero
    • , Aditi Mehta
    • , Lukasz Wujak
    • , Hector Cabrera-Fuentes
    • , Cho-Ming Chao
    • , Peter Braubach
    • , Saverio Bellusci
    • , Werner Seeger
    • , Andreas Günther
    • , Klaus T. Preissner
    • , Malgorzata Wygrecka
    • , Rajkumar Savai
    • , Dulce Papy-Garcia
    • , Gergana Dobreva
    • , Mathias Heikenwalder
    • , Soni Savai-Pullamsetti
    • , Thomas Braun
    •  & Guillermo Barreto
  • Research |

    Rewiring of bacterial two-component systems (TCSs) was achieved by DNA-binding domain swapping of the two largest response regulator families, which enables cross-species porting and provides a tool for identifying ligands for uncharacterized TCSs.

    • Sebastian R. Schmidl
    • , Felix Ekness
    • , Katri Sofjan
    • , Kristina N.-M. Daeffler
    • , Kathryn R. Brink
    • , Brian P. Landry
    • , Karl P. Gerhardt
    • , Nikola Dyulgyarov
    • , Ravi U. Sheth
    •  & Jeffrey J. Tabor

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