Toxicology articles from across Nature Portfolio

Toxicology is the scientific discipline concerned with the detection, evaluation and prevention of the toxic effects of substances that humans are exposed to. It has a key role in the development of new drugs, which are evaluated for potential toxic effects in preclinical studies, clinical trials and post-marketing studies with the aim of ensuring that their benefits outweigh their risks.

Latest Research and Reviews

Research
16 May 2023 | Open Access

Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity

There is currently no specific antidote for death cap mushroom poisoning treatment. Here, the authors identify STT3B as a druggable target and show that indocyanine green is a STT3B inhibitor that can block α-amanitin toxicity in cell lines, liver organoids and mice.
- Bei Wang
- , Arabella H. Wan
- & Qiao-Ping Wang
Nature Communications 14, 2241
Research
13 May 2023 | Open Access

Regorafenib inhibits EphA2 phosphorylation and leads to liver damage via the ERK/MDM2/p53 axis

The mechanism underlying regorafenib’s hepatotoxicity during anticancer therapy remains elusive. Here, the authors show regorafenib inhibits the phosphorylation of EphA2 at Ser897 resulting in the accumulation of p53 and contributes to hepatocytes apoptosis and the formation of hepatotoxicity.
- Hao Yan
- , Wentong Wu
- & Peihua Luo
Nature Communications 14, 2756
Research
12 May 2023 | Open Access

Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction

The SARS-CoV-2 drug remdesivir is a partial agonist for urotensin 2 receptor, leading to aberrant cardiomyocyte activity in vitro.
- Akiko Ogawa
- , Seiya Ohira
- & Fan-Yan Wei
Communications Biology 6, 511
Research
11 May 2023 | Open Access

The effect of Alnus incana (L.) Moench extracts in ameliorating iron overload-induced hepatotoxicity in male albino rats
- Fatma Abo-Elghiet
- , Shaza A. Mohamed
- & Samah Fathy Ahmed
Scientific Reports 13, 7635
Research
11 April 2023 | Open Access

CannaCount: an improved metric for quantifying estimates of maximum possible cannabinoid exposure
- Ashley M. Lambros
- , Kelly A. Sagar
- & Staci A. Gruber
Scientific Reports 13, 5869
Research
07 April 2023 | Open Access

Asperuloside attenuates cadmium-induced toxicity by inhibiting oxidative stress, inflammation, fibrosis and apoptosis in rats
- Zhiyang Kong
- , Chunhong Liu
- & Opeyemi Joshua Olatunji
Scientific Reports 13, 5698

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News and Comment

Research Highlights | 12 April 2023

That new car smell has a whiff of health hazards

Surface temperature drives emissions of chemicals that give a newly manufactured vehicle its signature aroma.

Nature 616, 414
News | 31 August 2022

Memory boost, forever chemicals and dark-matter signal

The latest science news, in brief.

Nature 609, 15
News | 24 August 2022

How to make water that’s full of holes

Embedded ‘nanocages’ help water dissolve large amounts of gas, and potential evidence that hominins walked on two legs seven million years ago.
- Benjamin Thompson
- & Shamini Bundell
Nature
News | 18 August 2022

How to destroy ‘forever chemicals’: cheap method breaks down PFAS

Disposing of these persistent substances often requires high pressures and temperatures.
- Giorgia Guglielmi
Nature
Correspondence | 24 May 2022

No chemical killer AI (yet)
- Marc-Michael Blum
Nature Machine Intelligence 4, 506-507
Comments & Opinion | 07 March 2022

Dual use of artificial-intelligence-powered drug discovery

An international security conference explored how artificial intelligence (AI) technologies for drug discovery could be misused for de novo design of biochemical weapons. A thought experiment evolved into a computational proof.
- Fabio Urbina
- , Filippa Lentzos
- & Sean Ekins
Nature Machine Intelligence 4, 189-191

All News & Comment

Toxicology articles from across Nature Portfolio

Latest Research and Reviews

Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity

Regorafenib inhibits EphA2 phosphorylation and leads to liver damage via the ERK/MDM2/p53 axis

Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction

The effect of Alnus incana (L.) Moench extracts in ameliorating iron overload-induced hepatotoxicity in male albino rats

CannaCount: an improved metric for quantifying estimates of maximum possible cannabinoid exposure

Asperuloside attenuates cadmium-induced toxicity by inhibiting oxidative stress, inflammation, fibrosis and apoptosis in rats

News and Comment

That new car smell has a whiff of health hazards

Memory boost, forever chemicals and dark-matter signal

How to make water that’s full of holes

How to destroy ‘forever chemicals’: cheap method breaks down PFAS

No chemical killer AI (yet)

Dual use of artificial-intelligence-powered drug discovery

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