Totipotent stem cells

  • Article
    | Open Access

    Embryos at the 2-cell (2C) stage are totipotent, and overexpression of Dux transcription factor convert embryonic stem cells (ESCs) to a 2C-like state. Here the authors show that DUX-mediated 2C-like reprogramming is associated with DNA damage at CTCF sites and CTCF depletion promotes 2Clike conversion.

    • Teresa Olbrich
    • , Maria Vega-Sendino
    •  & Sergio Ruiz