Tissue engineering articles within Nature Communications

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  • Article
    | Open Access

    Photo-crosslinking polymerization facilitates precise control of hydrogel formation for various applications including tissue engineering, but most existing photo-crosslinking methods fail to achieve deep-tissue penetration, especially within bone structures. Here the authors report a strategy of low-dose X-ray-activated polymerization that enables deep-tissue hydrogel formation.

    • Hailei Zhang
    • , Boyan Tang
    •  & Gang Han

  • Article
    | Open Access

    Suture repair is the current clinical treatment for meniscus tears, but inaccessible tears in company with re-tears susceptibility remain unresolved. Here the authors address these issues by developing a meniscus adhesive-based strategy for the seamless and dense reconstruction of torn meniscus.

    • Xihao Pan
    • , Rui Li
    •  & Hongwei Ouyang

  • Article
    | Open Access

    The application of engineered cardiac tissues is limited due to their immaturity and lack of functionality. Here, the authors develop an integrated culture platform featuring heart extracellular matrix cultured in a microfluidic chip to facilitate cardiac tissue development for versatile biomedical applications.

    • Sungjin Min
    • , Suran Kim
    •  & Seung-Woo Cho

  • Perspective
    | Open Access

    The development of human cellular models of aging that surpass the limitations of animal models of aging is urgent. Here, the authors explore the opportunities and limitations of cellular reprogramming to create reliable aging in vitro models and their potential for the discovery of anti-aging compounds.

    • Patricia R. Pitrez
    • , Luis M. Monteiro
    •  & Lino Ferreira

  • Article
    | Open Access

    Vascularization remains a significant challenge in organoid technology. Here, the authors develop a microfluidic platform that enhances organoid growth, function and maturation, by establishing functional perfusable vascular networks.

    • Clément Quintard
    • , Emily Tubbs
    •  & Xavier Gidrol

  • Article
    | Open Access

    Injectable pro-regenerative biomaterials are vital for developing minimally invasive regenerative treatment, but impeded by brittleness and lack of biological functions. Here the authors address these issues by engineering injectable functionalized composites that facilitate the sequential release of IL-4 and IGF-1 to regulate macrophages and stem cell behavior for enhanced in situ regeneration.

    • Yi Li
    • , Siyang Liu
    •  & Meifeng Zhu

  • Article
    | Open Access

    The functional heterogeneity of autophagy in endothelial cells during angiogenesis remains incompletely understood. Here, the authors apply a 3D angiogenesis-on-a-chip coupled with single-cell RNA sequencing to find distinct autophagy functions in two different endothelial cell populations during angiogenic sprouting.

    • Somin Lee
    • , Hyunkyung Kim
    •  & Noo Li Jeon

  • Q&A
    | Open Access

    Summary: Cultivated or cultured meat is promising to revolutionize the food industry in the coming years to decades, helping to resolve concerns related to the environmental impact and ethical implications linked to conventional meat production. We talked to Dr. Sandhya Sriram, the Group CEO and Co-founder of Shiok Meats Pte. Ltd., Singapore; Prof. Shulamit Levenberg, the former Dean of the Biomedical Engineering Department at the Technion, current Director of the Technion Center for 3D Bioprinting and The Rina & Avner Schneur Center for Diabetes Research, as well as the Co-founder and Chief Scientific Adviser of Aleph Farms, Israel; and Dr. Timothy Olsen, Head of Cultured Meat in the Life Science business at Merck KGaA, Germany; about this relatively new and quickly developing sector. They explain what their teams are working on, including the biggest recent accomplishments, speak about the main challenges facing the field and how they can be resolved, and share their visions about the future of cultivated meat, aiming to provide more equitable and sustainable access to nutritious food for the growing world population.

  • Article
    | Open Access

    Geometrical complexities of blood vessels alter biophysical behaviors of circulating tumor cells, influencing cancer metastasis. Here, the authors develop a 3D bioprinted in vitro brain blood vessel-on-a-chip to investigate continuities between vascular geometry and metastatic cancer development.

    • Wonbin Park
    • , Jae-Seong Lee
    •  & Dong-Woo Cho

  • Article
    | Open Access

    Current methods to generate spheroids are associated with low production throughputs, limiting clinical and industrial translation. Here the authors present a clean ultra-high-throughput in-air microfluidic platform for mass production of lumenogenic embryoid bodies and functional cardiospheres.

    • Bas van Loo
    • , Simone A. ten Den
    •  & Jeroen Leijten

  • Article
    | Open Access

    The use of biomaterial scaffolds-based cartilage grafts could potentially innovate the Osteoarthritis (OA) treatment, but has been limited by toxicity concerns and invasive surgical procedures. Here, the authors report an injectable and biodegradable piezoelectric hydrogel with ultrasound activation to offer a minimally invasive approach for OA treatment.

    • Tra Vinikoor
    • , Godwin K. Dzidotor
    •  & Thanh D. Nguyen

  • Article
    | Open Access

    Flexible electronic hydrogels that allow conformal tissue integration, online precision diagnosis, and simultaneous tissue regeneration are desired for advancing the treatment of myocardial infarction. Here, the authors report a chronological adhesive hydrogel patch integrating diagnostic and therapeutic functions through mechanophysiological monitoring and electrocoupling therapy.

    • Chaojie Yu
    • , Mingyue Shi
    •  & Junjie Li

  • Article
    | Open Access

    Therapeutic options for myocardial infarction therapy remain limited. Here the authors report the application of an optimized liquid crystal substrate in the mass production and effective preconditioning of cardiospheres, which could generate cardiospheres with improved cell bioactivity and resistance to oxidative stress for myocardial infarction therapy.

    • Yingwei Wang
    • , Qi Li
    •  & Zheng Wu

  • Article
    | Open Access

    Current limb salvage techniques for the treatment of the osteopathic non-unions still have several drawbacks that may prolong the duration of treatment. Here, Lin et al., propose using an osteoinductive (BMP-2 eluting) intramedullary and biodegradable implant to achieve early bony bridging and show that pin tract infection or docking site non-union can be avoided in experimental animal models of large bone defects.

    • Sien Lin
    • , Hirotsugu Maekawa
    •  & Yunzhi Peter Yang

  • Article
    | Open Access

    Biomaterials that can be non-invasively activated to promote bone growth would be useful tools to repair bone defects in patients with comorbidities like inflammation or impaired osteogenesis. Here, the authors develop a composite membrane that can be stimulated by an external magnetic field and use it to correct skull defects in rats treated to reflect such comorbidities.

    • Wenwen Liu
    • , Han Zhao
    •  & Xuliang Deng

  • Article
    | Open Access

    Traditional 2D cell culture platforms do not accurately reflect the physiology of human tumors. Here, authors combine bioprinting and high-speed live cell interferometry with machine learning to measure drug sensitivity at single-organoid resolution in a label-free manner.

    • Peyton J. Tebon
    • , Bowen Wang
    •  & Alice Soragni

  • Article
    | Open Access

    It remains unclear how cells respond to complex extracellular geometries at the mesoscale. Here, the authors study the organization of bone cells in landscapes with varying curvatures, observing a preference for local concavities, multicellular bridging, and collective stress fiber orientation.

    • Sebastien J. P. Callens
    • , Daniel Fan
    •  & Amir A. Zadpoor

  • Article
    | Open Access

    Bioengineered livers using decellularized scaffolds have been considered as an alternative to donor organs. Here, the authors modulate biophysical properties of decellularized scaffolds by crosslinking with nano-graphene oxide, thereby greatly enhancing therapeutic efficacy of bioengineered livers.

    • Da-Hyun Kim
    • , Min-Ji Kim
    •  & Kyung-Sun Kang

  • Article
    | Open Access

    The mechanical properties of biological tissues are key to their integrity and function. Here, the authors engineer 3D microtissues from optogenetically modified fibroblasts and use light to quantify tissue elasticity and strain propagation using their own constituent cells as internal actuators.

    • Adrien Méry
    • , Artur Ruppel
    •  & Thomas Boudou

  • Article
    | Open Access

    Volumetric additive manufacturing of protein scaffolds has a wide range of possible biomedical applications. Here the authors report on the bioprinting of unmodified silk sericin and silk fibroin inks with shape-memory and tuneable mechanical properties and demonstrate the potential of the inks in different applications.

    • Maobin Xie
    • , Liming Lian
    •  & Yu Shrike Zhang

  • Article
    | Open Access

    Islet transplantation for type 1 diabetes management is hindered by the life-long need for immunosuppressive medications. Here, the authors report an islet encapsulation device with local anti-rejection drug release that achieves long-term diabetes reversal in male rats and reduces drug-related toxicity.

    • Jesus Paez-Mayorga
    • , Jocelyn Nikita Campa-Carranza
    •  & Alessandro Grattoni

  • Article
    | Open Access

    Host versus graft reaction is a major impediment to CAR-T cell immune therapy in allogeneic settings. Authors show here that CAR-T cells, engineered to be deficient in MHC I expression but to express the NK inhibitor HLA-E, are resistant to destruction by both T and NK cells of the host.

    • Sumin Jo
    • , Shipra Das
    •  & Julien Valton

  • Article
    | Open Access

    Limited stem cells and mismatched interface fusion have plagued biomaterial-mediated cranial reconstruction. Here, the authors engineer an instantly fixable and self-adaptive scaffold to promote calcium chelation and interface integration, regulate macrophage M2 polarization, and recruit endogenous stem cells.

    • Gonggong Lu
    • , Yang Xu
    •  & Xingdong Zhang

  • Article
    | Open Access

    Protoissues have received a lot of attention for studying cell interaction and for biomedical engineering. Here, the authors demonstrate a high-throughput, bottom-up approach to assemble spatial programmable prototissues based on the magnetic Archimedes affect and demonstrate biomedical application for producing NO for vasodilation.

    • Xiangxiang Zhang
    • , Chao Li
    •  & Xiaojun Han

  • Article
    | Open Access

    Mechanical forces in lungs facilitate breathing motions. Here the authors use a microfluidic human lung alveolus chip to study influenza infection and find that mechanical forces from active chips also induce innate inflammatory responses via, at least partially, signaling from TRPV4 and RAGE, thereby implicating them as potential therapeutic targets for lung inflammation.

    • Haiqing Bai
    • , Longlong Si
    •  & Donald E. Ingber

  • Article
    | Open Access

    How double strand breaks (DSBs) are repaired within the plant 45S rDNA repeats is unclear. Here, the authors show that Cas9-mediated DSBs in 45S rDNA are mainly repaired by cNHEJ and describe CRISPR-Kill as a tool for organ-specific cell elimination by targeting functional repetitive DNA in Arabidopsis.

    • Angelina Schindele
    • , Fabienne Gehrke
    •  & Holger Puchta

  • Article
    | Open Access

    Vascularization is critical for cranial bone growth, maintenance, and healing, but it remains unknown how blood vessels are spatially distributed in the calvarium, and how they interact with skeletal progenitors during these processes. Here, the authors apply a quantitative light-sheet imaging platform to visualize and analyze the relationship between blood vessels and skeletal progenitors throughout the murine calvarium.

    • Alexandra N. Rindone
    • , Xiaonan Liu
    •  & Warren L. Grayson

  • Article
    | Open Access

    Developing effective treatments for noncompressible hemorrhages remains a challenge. Here the authors engineer alkylated chitosan sponges with highly interconnective microchannels and demonstrate anti-infective activity, as well as higher pro-coagulant, hemostatic and wound healing capacities compared to clinically-used materials in rat and pig liver models.

    • Xinchen Du
    • , Le Wu
    •  & Meifeng Zhu

  • Article
    | Open Access

    Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids. Here the authors combine human brain extracellular matrix and culture in a microfluidic device to promote structural and functional maturation of human brain organoids.

    • Ann-Na Cho
    • , Yoonhee Jin
    •  & Seung-Woo Cho

  • Article
    | Open Access

    Shape memory scaffolds are needed for minimally invasive tissue repair and void filling. Here the authors report on the development of 4D printed polycarbonate-based scaffolds with surface degradation properties which fill voids without deforming tissue and allow for tissue ingrowth with reduced immune response.

    • Andrew C. Weems
    • , Maria C. Arno
    •  & Andrew P. Dove

  • Article
    | Open Access

    Current methods for the modular assembly of biomaterials are associated with limitations. Here the authors implement vapor-phase deposition to fabricate 3D polymeric materials that permit biomolecule functionalization, tunable mass transport and mechanical properties, as well as control over boundaries between compartments, and analyze the behavior of 3D encapsulated cells.

    • Chih-Yu Wu
    • , Ting-Ying Wu
    •  & Hsien-Yeh Chen

  • Article
    | Open Access

    Fabrication of dynamic, reversible and biocompatible scaffolds with non-invasive external triggers has so far been limited. Here, the authors report on the creation of 3D printed scaffolds with Janus structure that produce nanovibrations when exposed to ultrasound, promoting bone regeneration.

    • Sandra Camarero-Espinosa
    •  & Lorenzo Moroni

  • Article
    | Open Access

    The creation of biomaterials which are resorbable and have biomimetic mechanical properties is key to successful tissue engineering. Here the authors report on the creation of a new biopolymer where the mechanical properties can be tuned by changing the ratios of cis:trans double bonds in the backbone.

    • Mary Beth Wandel
    • , Craig A. Bell
    •  & Matthew L. Becker

  • Review Article
    | Open Access

    Large-scale meat production can have negative impacts on public health, the environment and animal welfare. In this Review, the authors consider plant-based and cell-based approaches to meat production and the challenges they face.

    • Natalie R. Rubio
    • , Ning Xiang
    •  & David L. Kaplan

  • Article
    | Open Access

    Brain organoids are important tools to study early development and disease but little is known of their network activity and plasticity. Here the authors generate iPSC-derived neuronal organoids that display early network formation and maturation with evidence for a GABA polarity switch and long-term potentiation.

    • Maria-Patapia Zafeiriou
    • , Guobin Bao
    •  & Wolfram-Hubertus Zimmermann

  • Article
    | Open Access

    3D liver organoids hold great promise for regenerative medicine but the use of ill-defined matrices limits their potential. Here, the authors generate human and mouse liver organoids using a chemically defined matrix, and reveal a link between matrix stiffness and organoid growth that does not require acto-myosin contraction.

    • Giovanni Sorrentino
    • , Saba Rezakhani
    •  & Kristina Schoonjans

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