Tissue engineering and regenerative medicine articles within Nature Communications

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  • Article
    | Open Access

    Prelithiation can introduce controllable amounts of lithium within porous silicon, however it yields a highly reactive material unsuitable for biomedicine. In this study, the authors present a strategy to lithiate porous silicon nanowires, resulting in a biocompatible and bioresorbable material.

    • Martti Kaasalainen
    • , Ran Zhang
    •  & Ciro Chiappini

  • Article
    | Open Access

    Inflammatory diseases such as rheumatoid arthritis are associated with high reactive oxygen species levels. Here, the authors report on 2D metal-organic frameworks as an artificial antioxidase with the same manganese coordination centre as two natural enzymes, and demonstrate their anti-inflammatory effects and anti-arthritic effects in vivo.

    • Bowen Yang
    • , Heliang Yao
    •  & Jianlin Shi

  • Article
    | Open Access

    Cellular responses to mechanical stimulation have emerged as an important area of research. Here, the authors use cryoprotectant to control the pore size and mechanical properties of porous scaffolds without changing the scaffold composition to allow for the study of cellular mechano-responsiveness in 3D.

    • Shumeng Jiang
    • , Cheng Lyu
    •  & Yanan Du

  • Article
    | Open Access

    The promise of stem cell therapy for treating central nervous system disease is limited by low stem cell transplantation survival rates and poorly controlled cell fate. Here, the authors develop a biodegradable nanoscaffold for spinal cord injury that enhances transplantation and differentiation of neural stem cells and delivers drugs.

    • Letao Yang
    • , Sy-Tsong Dean Chueng
    •  & Ki-Bum Lee

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