Thioredoxins articles within Nature Communications

Featured

• Article
  23 April 2024 | Open Access

  Temporal coordination of the transcription factor response to H₂O₂ stress

  H₂O₂ stress is known to activate a slew of transcription factors that restore redox balance. Here, the authors use live-cell imaging and single-cell analysis to reveal that the transcription factors that are activated and their timing of activation is dose dependent.

  • Elizabeth Jose
  • , Woody March-Steinman
  •  & Andrew L. Paek

• Article
  09 September 2020 | Open Access

  A role for annexin A2 in scaffolding the peroxiredoxin 2–STAT3 redox relay complex

  Peroxiredoxin 2 (Prx2) was previously shown to transfer H₂O₂-derived oxidative equivalents to STAT3, generating disulfide-linked dimers and tetramers. Here the authors show that the interaction between Prx2 and STAT3 at the plasma membrane is mediated by the membrane chaperone annexin A2; suggesting that the redox relay complex is part of a membrane signaling domain.

  • Deepti Talwar
  • , Joris Messens
  •  & Tobias P. Dick

• Article
  07 April 2020 | Open Access

  Quantitative assessment of the determinant structural differences between redox-active and inactive glutaredoxins

  Glutaredoxins play a central role in numerous biological processes including cellular redox homeostasis and Fe-S cluster biogenesis. Here the authors establish the molecular basis for glutaredoxin redox catalysis through comprehensive biochemical and structural analyses.

  • Linda Liedgens
  • , Jannik Zimmermann
  •  & Marcel Deponte

• Article
  21 June 2019 | Open Access

  A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage

  Thioredoxin reductase (TrxR) plays a crucial part in regulating cellular redox homeostasis. Here, the authors developed a fluorescent probe composed of a five-membered disulphide, a coumarin fluorophore and a urea linker that detects TrxR activity with fast response and high selectivity.

  • Xinming Li
  • , Baoxin Zhang
  •  & Jianguo Fang