Testicular cancer

  • Article
    | Open Access

    Testicular germ cell tumors are highly heritable, and the authors present the largest genome association study, identifying 22 novel loci, which account for a third of those identified to date. Implicated pathways include male germ cell development and differentiation, and chromosomal segregation.

    • John Pluta
    • , Louise C. Pyle
    •  & Christian Kubisch
  • Article
    | Open Access

    Most testicular germ-cell tumours are exquisitely sensitive to platinum-based chemotherapies, but little is known about why 10% are resistant. Here, the authors explore the potential underlying mechanisms by probing the genomic landscape of platinum-resistant disease.

    • Chey Loveday
    • , Kevin Litchfield
    •  & Clare Turnbull
  • Article
    | Open Access

    This genome-wide association study identifies four novel risk loci for testicular germ cell tumour, and provides functional correlation between a disease-associated variant and gene expression in patient samples for one of the identified loci.

    • Kevin Litchfield
    • , Amy Holroyd
    •  & Clare Turnbull