T-helper 17 cells

T-helper 17 cells are a specialized population of T cells that produce a pro-inflammatory molecule known as interleukin-17. They are important for immunity to certain bacterial and fungal infections. They also contribute to certain inflammatory conditions, such as inflammatory bowel disease.

Latest Research and Reviews

  • Research
    | Open Access

    The master transcription factor RORγt, encoded by the RORC gene, controls the polarization of CD4+ T cells expressing interleukin-17 (Th17). Here the authors describe several regulatory elements at the RORC locus that are recognized by NFAT and NFkB to induce a permissive epigenetic configuration of the RORC gene for RORγt expression and Th17 differentiation.

    • Hanane Yahia-Cherbal
    • , Magda Rybczynska
    • , Domenica Lovecchio
    • , Tharshana Stephen
    • , Chloé Lescale
    • , Katarzyna Placek
    • , Jérome Larghero
    • , Lars Rogge
    •  & Elisabetta Bianchi
  • Research |

    PlGF is an important vascular endothelial growth factor which has not been widely implicated in immune function. Kim and colleagues demonstrate that PlGF is selectively secreted by TH17 cells to promote angiogenesis but in turn also strongly supports TH17 cell differentiation yet inhibits regulatory T cell function.

    • Seung-Ah Yoo
    • , Mingyo Kim
    • , Min-Cheol Kang
    • , Jin-Sun Kong
    • , Ki-Myo Kim
    • , Saseong Lee
    • , Bong-Ki Hong
    • , Gi Heon Jeong
    • , Jinhee Lee
    • , Min-Gyeong Shin
    • , Yeon-Gu Kim
    • , Ivana Apicella
    • , Valeria Cicatiello
    • , Sandro De Falco
    • , Chong-Hyeon Yoon
    • , Chul-Soo Cho
    • , Zae Young Ryoo
    • , Seung-Hyo Lee
    •  & Wan-Uk Kim
    Nature Immunology 20, 1348-1359
  • Research
    | Open Access

    Short-chain fatty acids (SCFAs) have immunomodulatory effects, but the underlying mechanisms are still unclear. Here the authors show that a SCFA, pentanoate, suppresses autoimmune inflammation in mouse models of colitis and multiple sclerosis via epigenetic modulation of immune cell metabolic and functional pathways.

    • Maik Luu
    • , Sabine Pautz
    • , Vanessa Kohl
    • , Rajeev Singh
    • , Rossana Romero
    • , Sébastien Lucas
    • , Jörg Hofmann
    • , Hartmann Raifer
    • , Niyati Vachharajani
    • , Lucia Campos Carrascosa
    • , Boris Lamp
    • , Andrea Nist
    • , Thorsten Stiewe
    • , Yoav Shaul
    • , Till Adhikary
    • , Mario M. Zaiss
    • , Matthias Lauth
    • , Ulrich Steinhoff
    •  & Alexander Visekruna
  • Research
    | Open Access

    Ubiquitination may control protein stability or function. Here the authors show that an ubiquitination enzyme, Hectd3, ubiquitinates Stat3 and Malt1 to modulate their function but not degradation in T cells, and thereby promoting the differentiation of pathogenic Th17 cells and susceptibility to a mouse model of multiple sclerosis.

    • Jonathan J. Cho
    • , Zhiwei Xu
    • , Upasana Parthasarathy
    • , Theodore T. Drashansky
    • , Eric Y. Helm
    • , Ashley N. Zuniga
    • , Kyle J. Lorentsen
    • , Samira Mansouri
    • , Joshua Y. Cho
    • , Mariola J. Edelmann
    • , Duc M. Duong
    • , Torben Gehring
    • , Thomas Seeholzer
    • , Daniel Krappmann
    • , Mohammad N. Uddin
    • , Danielle Califano
    • , Rejean L. Wang
    • , Lei Jin
    • , Hongmin Li
    • , Dongwen Lv
    • , Daohong Zhou
    • , Liang Zhou
    •  & Dorina Avram

News and Comment