T cells

T cells are white blood cells that are important for adaptive immunity. They have unique cell surface receptors that are generated by randomly assorting genes. These receptors allow T cells to sense and respond to diverse types of infection.

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Latest Research and Reviews

  • Research | | open

    Despite the current human CD4 memory T cell stratification by CD45RA/CCR7, functional heterogeneities still exist within the respective subsets. Here the authors show that several surface markers, including KLRB1, KLRG1, GPR56 and KLRF1, help to further refine the subsetting of human CD4 memory T cells and provide insights for their differentiation.

    • Kim-Long Truong
    • , Stephan Schlickeiser
    • , Katrin Vogt
    • , David Boës
    • , Katarina Stanko
    • , Christine Appelt
    • , Mathias Streitz
    • , Gerald Grütz
    • , Nadja Stobutzki
    • , Christian Meisel
    • , Christina Iwert
    • , Stefan Tomiuk
    • , Julia K. Polansky
    • , Andreas Pascher
    • , Nina Babel
    • , Ulrik Stervbo
    • , Igor Sauer
    • , Undine Gerlach
    •  & Birgit Sawitzki
  • Research | | open

    Viral rebound following discontinuation of antiretroviral therapy (ART) is a major obstacle for HIV cure. Here, the authors show that adoptive cellular therapy using autologous Env-specific T cells augmented by therapeutic vaccination can control viral rebound after ART interruption in a SHIV macaque model.

    • Jin Fan
    • , Hua Liang
    • , Xiaolin Ji
    • , Shuo Wang
    • , Jing Xue
    • , Dan Li
    • , Hong Peng
    • , Chuan Qin
    • , Cassian Yee
    •  & Yiming Shao
  • Research | | open

    Mucosal-associated invariant T (MAIT) cells express invariant TRAV1/TRAJ33 TCR-α gene segments and detect antigens presented by MR1. Here the authors show that atypical, MR1-restricted MAIT populations that include both Trav1+ and Trav1- cells are found in both Traj33-deficient mice and human peripheral blood.

    • Hui-Fern Koay
    • , Nicholas A. Gherardin
    • , Calvin Xu
    • , Rebecca Seneviratna
    • , Zhe Zhao
    • , Zhenjun Chen
    • , David P. Fairlie
    • , James McCluskey
    • , Daniel G. Pellicci
    • , Adam P. Uldrich
    •  & Dale I. Godfrey
  • Reviews |

    Tuft cells captured the attention of immunologists with recent discoveries linking them to type 2 immunity in the small intestine. As described here, these rare secretory epithelial cells act as chemosensory sentinels that detect and relay responses through immune and neuronal cells.

    • Christoph Schneider
    • , Claire E. O’Leary
    •  & Richard M. Locksley
  • Research |

    Tissue-resident memory T (TRM) cells have been studied mainly in mouse models. Schumacher and colleagues have developed an imaging technology to track in real time skin-resident human CD8+ TRM cells in situ.

    • Feline E. Dijkgraaf
    • , Tiago R. Matos
    • , Mark Hoogenboezem
    • , Mireille Toebes
    • , David W. Vredevoogd
    • , Marjolijn Mertz
    • , Bram van den Broek
    • , Ji-Ying Song
    • , Marcel B. M. Teunissen
    • , Rosalie M. Luiten
    • , Joost B. Beltman
    •  & Ton N. Schumacher
    Nature Immunology 20, 756-764

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