Synthetic biology

Definition

Synthetic biology is the design and construction of new biological parts, devices, and systems, and the re-design of existing, natural biological systems for useful purposes.

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Latest Research and Reviews

  • Reviews |

    The emergence of synthetic fluorescent nucleobases that can be incorporated into DNA and RNA in place of their natural counterparts has enabled new tools and technologies with applications in chemistry, biology and biomedicine. This Review discusses chemical insights into canonical and non-canonical nucleobase designs, relating structure to properties.

    • Wang Xu
    • , Ke Min Chan
    •  & Eric T. Kool
  • Research |

    A microfluidics method to generate giant, copolymer-stabilized liposomes is presented. These vesicles are functionalized with distinct proteins to recapitulate cellular processes.

    • Marian Weiss
    • , Johannes Patrick Frohnmayer
    • , Lucia Theresa Benk
    • , Barbara Haller
    • , Jan-Willi Janiesch
    • , Thomas Heitkamp
    • , Michael Börsch
    • , Rafael B. Lira
    • , Rumiana Dimova
    • , Reinhard Lipowsky
    • , Eberhard Bodenschatz
    • , Jean-Christophe Baret
    • , Tanja Vidakovic-Koch
    • , Kai Sundmacher
    • , Ilia Platzman
    •  & Joachim P. Spatz
  • Reviews |

    Identifying which genes in a genome are essential for survival has been a long-standing goal of geneticists. This Review discusses our evolving understanding of cellular gene essentiality across diverse organisms. It describes how essentiality is often non-absolute but is instead dependent on the environment or genetic background and how this knowledge can be exploited therapeutically.

    • Giulia Rancati
    • , Jason Moffat
    • , Athanasios Typas
    •  & Norman Pavelka
  • Research |

    A fluorescence-based assay is used to screen cyclic peptides for their activity in preventing protein misfolding, an event that can generate pathogenic aggregates that lead to diseases such as Alzheimer's disease or amyotrophic lateral sclerosis.

    • Ilias Matis
    • , Dafni Chrysanthi Delivoria
    • , Barbara Mavroidi
    • , Nikoletta Papaevgeniou
    • , Stefania Panoutsou
    • , Stamatia Bellou
    • , Konstantinos D. Papavasileiou
    • , Zacharoula I. Linardaki
    • , Alexandra V. Stavropoulou
    • , Kostas Vekrellis
    • , Nikos Boukos
    • , Fragiskos N. Kolisis
    • , Efstathios S. Gonos
    • , Marigoula Margarity
    • , Manthos G. Papadopoulos
    • , Spiros Efthimiopoulos
    • , Maria Pelecanou
    • , Niki Chondrogianni
    •  & Georgios Skretas

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