Chemical synthesis

Chemical synthesis is the process by which one or more chemical reactions are performed with the aim of converting a reactant or starting material into a product or multiple products. Chemical synthesis is at the heart of much chemistry research as it is the basis for discovering compounds with new physical or biological properties.

Latest Research and Reviews

News and Comment

  • Comments and Opinion
    | Open Access

    The activation of very inert small molecules generally requires highly reactive activating species, but the high energy of these species makes their regeneration, and thus also catalytic turnover of the reaction, difficult to achieve. Here, the authors highlight the formidable challenge of overcoming the tradeoff between activating power and catalytic turnover in the context of main-group ambiphiles.

    • Rian D. Dewhurst
    • , Marc-André Légaré
    •  & Holger Braunschweig
  • Research Highlights |

    Two templates can stack together to enable the formation of a large macrocycle, providing they bind cooperatively to the target. The approach may enable the synthesis of very large macrocycles using relatively simple templates.

    • Stephen G. Davey
  • Comments and Opinion
    | Open Access

    After two decades of steady growing, symbiotic merger of organocatalysis with emerging electrochemical and photochemical tools are envisioned as hot topics in the coming decade. Here, these trends are discussed in parallel to the implementation of artificial intelligence-based technologies, which anticipate a paradigm shift in catalyst design.

    • José M. Lassaletta
  • Comments and Opinion |

    The gap between fundamental academic research and the applied industrial research that is necessary to ensure real-world applications can be bridged by engaging in well-defined collaborative academia–industry projects and fostering better communication between the scientists involved in them.

    • Danielle Schultz
    •  & Louis-Charles Campeau
    Nature Chemistry 12, 661-664